Frontiers in Cardiovascular Medicine

Um, and if a liver is overbo-burdened with keep taking toxins, you're gonna see, um, impacts to some of those metabolic markers as well, um, that can be contributors to cardiovascular disease.

A separate twenty twenty-four systematic review in Frontiers in Cardiovascular Medicine found that cadmium specifically lowers nitric oxide while raising a compound called endothelin-1, which constricts vessels and at that same state alters the enzymes that really help to make LDL cholesterol not harmful, which is the exact chemistry behind plaque formation.

We know that higher levels of LDL often correlate to higher levels of plaque accumulation and formation in the body.

And in a twenty twenty-one study published in the Journal of Biological Chemistry, where researchers found that iron overload directly switches on the genes responsible for cholesterol synthesis inside vascular endothelial cells.