Fluphenazine

It was released in 2009.

So what are we doing here? But before we get into that, we should look at where did the long-acting injectables first originate? Well, the first FDA-approved long-acting injectable was a formulation of flufenazine, that's brand name Prolixin, which came out in 1966, followed by haloperidol, deconate 20 years later in 1986.

Now, these LAIs are still used today with some regularity and are much less expensive than some of the newer alternatives, although problems like higher rates of EPS, especially tardive dyskinesia, and the necessity of oral overlap and potentially more pain with the sesame oil formulations during injection somewhat limits their use.

All right, so the first atypical LAI was Risperidone, specifically Risperdal Consta, released in 2003.

It does work a little bit differently, and so we'll have to, we'll learn about that.

Next, we have, uh, fluphenazine or Prolixin, came out in 1959.

I have used Prolixin.

This is one that it, it works very similarly to haloperidol, Haldol, and so a lot of people get Haldol acutely over and over and over again, and they hate it because they've had it so many times.

So I've often heard, you know, since Prolixin works similarly, if a patient is kind of adverse to the idea of Haldol, that Prolixin-- They may be like, "Well, I've never heard of Prolixin." So if you wanted to use Haldol and the patient refuses, Prolixin is a decent option.

Um, it's also available as a long-acting injectable.

So we don't have a lot that are available as long-acting injectables, and this is one of them, so it does have some use still.

We'll go into detail on it.

He spent the next several years being arrested for larceny, driving drunk, assault, and armed robbery.

While in prison for the robbery, he was treated with the antipsychotic drug Prolixin.

He was free again in April of 1976.

His cousin got him a real job, but Gilmore spent much of his time drunk and committing more petty thefts.

The final fatal bullet was to the back of her head just as she got through on 999 calling for help.

The tape of the call and that final moment was played during the trial.

Young staged the scene to look like a drug-related crime as he sprinkled powdered sugar over Harry's body.

Did he really think that they wouldn't be able to tell that that wasn't cocaine? The evidence that got him busted was a tape recording of a conversation he had with Harry on the night before the killings in which they had agreed to meet at the cottage the next morning.

Some psychiatric drugs can also lead to quite severe depression.

Lithium can do this, Prolixin can do this, and also Haldol can do this.

And so if you have a psychiatric condition, you take one of these four, and you also have depression symptoms, you might wanna talk to your psychiatrist or your primary care provider about, "Let's try something else to see if my depression gets better." Parkinson's drugs is the next big class.

They absolutely can have some pretty severe depression side effects.