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First principle

First principle

Search complete. 97 mentions across 22 episodes found for "First principle".

Sep 19, 2026

Justin CarbonneauHOST
0:11
Yeah, great to have you back.
Justin CarbonneauHOST
0:12
We like to pop on these once a month and just... talk to you about the macro landscape, the first principles behind how you look at the markets and the economy and the things that you're sort of paying attention to under the surface and some of the nuts and bolts of how markets are operating and what they're reacting to.
Justin CarbonneauHOST
0:33
And this was a pretty kind of busy week.
Justin CarbonneauHOST
0:36
I mean, you had the Fed with its first interest rate increase in three years.

24 MINS LATER

Andy ConstanGUEST
24:51
It's against that.
Andy ConstanGUEST
24:52
And so it's just an interesting dynamic.
Jack ForehandHOST
24:56
Might be too basic of a question, but we like to do first principles here.
Jack ForehandHOST
24:59
I want to ask you about the relationship between what the Fed does and long-term interest rates, because it was interesting to me that on Twitter coming into this, there was a debate.
Jeffrey EdwardsNARRATOR
6:42
For both those who do not, and those who do know, fancy the former, that they in this manner possess knowledge, but those who know possess it in reality, so that it is impossible that a thing of which there is knowledge simply should subsist in any other way.
Jeffrey EdwardsNARRATOR
7:01
whether therefore there is any other mode of knowing we shall tell hereafter but we say also that we obtain knowledge through demonstration but i call demonstration a scientific syllogism and i mean by scientific that according to which from our possessing it we know if then to know is what we have laid down it is necessary that demonstrative science should be from things true first immediate more known than prior to and the causes of the conclusion for thus there will be the appropriate first principles of whatever is demonstrated now syllogism will subsist even without these but demonstration will not since it will not produce knowledge it is necessary then that they should be true since we cannot know that which does not subsist for instance that the diameter of a square is commensurate with its side but it must be from things first and indemonstrable or otherwise a man will not know them because he does not possess the demonstration of them for to know those things of which there is demonstration not accidentally is to possess demonstration but they must be causes and more known and prior causes indeed because we then know scientifically when we know the cause and prior since they are causes previously known also not only according to the other mode by understanding what they signify but by knowing that they are moreover they are prior and more known in two ways for what is prior in nature is not the same as that which is prior in regard to us nor what is more known simply the same as what is more known to us Now, I call things prior, and more known to us, those which are nearer to sense.
Jeffrey EdwardsNARRATOR
9:13
And things prior, and more known simply, those which are more remote from sense.
Jeffrey EdwardsNARRATOR
9:19
And those things are most remote, which are especially universal, and those nearest, which are singular, and these are mutually opposed.
Jeffrey EdwardsNARRATOR
10:08
Enunciation is either part of contradiction, and contradiction is an opposition which has no medium in respect to itself.
Jeffrey EdwardsNARRATOR
10:19
but that part of contradiction which declares something of somewhat is affirmation and that which signifies something from somewhat is negation of an immediate syllogistic principle i call that the thesis which it is not possible to demonstrate nor is it necessary that he should possess it who intends to learn anything but what he who intends to learn anything must necessarily possess that i call an axiom for there are certain things of this kind and in denominating these we are accustomed generally to use this name but of thesis that which receives either part of contradiction as for instance i mean that a certain thing is or that it is not is hypothesis but that which is without this is definition for definition is a thesis since the arithmetician lays down unity to be that which is indivisible according to quantity yet it is not hypothesis since what unity is and that unity is are not the same thing notwithstanding since we must believe in and know a thing from possessing such a syllogism as we call demonstration and this is because these are so of which syllogism consists it is necessary not only to have a previous knowledge of the first or all or some things but that they should be more known for that on account of which any thing exists always exists itself in a greater degree for example that on account of which we love is itself more beloved hence if we know and believe on account of things first we also know and believe those first things in a greater degree because through them we know and believe things posterior A man, however, cannot believe more than what he knows, those things which he does not know, nor with respect to which he is better disposed than if he knew.
Jeffrey EdwardsNARRATOR
12:41
This, however, will happen unless some one should previously know of those who give credence through demonstration, since it is more necessary to believe either in all or in certain first principles than in the conclusion.
Jeffrey EdwardsNARRATOR
12:57
It is not only, however, requisite, that he who is to possess knowledge through demonstration should know in a greater degree first principles, and believe rather in them than in the thing demonstrated, but also that nothing else should be more credible or more known to him than the opposites of the principles, from which a syllogism of contradeception may consist, since it behoves him who possesses knowledge singly to be unchangeable.
Jenna StoreyHOST
40:01
So this is a question for William.
Jenna StoreyHOST
40:04
And the questioner says, the description of the new school sounds like it's philosophically based in pragmatism, focused on problem solving rather than on first principles.
Jenna StoreyHOST
40:14
By contrast, the questioner says, the most distinctive public policy school I know of, the questioner, is at Pepperdine University, where I believe the program begins with the study of the American founding and more generally with attention to great texts and to history.
Jenna StoreyHOST
40:28
Do you envision a curriculum that begins with first principles and American constitutional thought and practice? Or can interdisciplinary social science proceed without pre-pragmatic thought? I thought that was an interesting term, pre-pragmatic thought.
Jenna StoreyHOST
40:42
I like it.
William HowellGUEST
40:43
I do too.
William HowellGUEST
42:12
That's the sort of pragmatism piece that I'm leaning into.
William HowellGUEST
42:15
But in order to do that, in order to do that properly, in order to be able to do that fully, you need to be able to see more than just what an immediate exchange or an immediate transaction involves.
Seven VIIINARRATOR
20:08
cicero on the nature of gods 1.10 it was the opinion of annex amanda that gods have a beginning at long intervals rising and setting and that they are the innumerable worlds but who of us can think of god except as immortal End of Part 2 Recording by Seven VIII.
Seven VIIINARRATOR
20:34
ANCIENT GREEK PHILOSOPHER-SCIENTISTS part three fragmented testimonials on annexmenes of melitos translated by arthur fairbanks in the first philosophers of greece fragment of annexmenes of melitos air is the nearest to an immaterial thing for since we are generated in the flow of air it is necessary that it should be infinite and abundant because it is never exhausted testimonials on annexmenes of melitos aristotle meteorology two dot one most of the earlier students of the heavenly bodies believed that the sun did not go underneath the earth but rather round the earth and this region entreated it disappeared from view and produced night because the earth was so high toward the north simplicius comments on aristotle's on the heavens two seventy three b forty five he regarded the first principle as unlimited but not as undefined for he called it air thinking that air had a sufficient adaptability to change simplicius comments on aristotle's physics thirty two r one forty nine thirty two of this one writer alone theoprastos in his account of the physicists uses the words greek of texture the rest of course spoke of greek simplicius comments on aristotle's physics 2,57 v.
Seven VIIINARRATOR
22:24
Some say that the universe always existed, not that it has always been the same, but rather, it successively changes its character in certain periods of time, as, for instance, Anaxmenes, Enherikles, and Diogenes.
Seven VIIINARRATOR
22:39
Aristotle, On the Heavens, 2.13, 294 b.
Seven VIIINARRATOR
22:51
Aristotle, Meteorology, 2.7, 365 Anaxmenes says that the earth was wet, and when it dried it broke hard, and that the earthquakes are due to the breaking and falling of hills.
Seven VIIINARRATOR
23:04
Accordingly, earthquakes occur in droughts.
Seven VIIINARRATOR
23:07
and in rainy seasons also they occur in drought as has been said because the earth dries and breaks apart and it also crumbles when it is wet through with waters aristotle metaphysics one dot three nine eighty four five and many regarded air as the first principle plutarch on the principle of cold seven or three according to annex menes the early philosopher we should not neglect either cold or heat in being but should regard them as common experiences of matter which are incident to its changes he says that the compressed and the condensed state of matter is cold while the rarefied and relaxed a word he himself uses state of it is heat whence he says it is not strange that men breathe hot and cold out of the mouth for the breath is cooled as it is compressed and condensed by the lips but when the mouth is relaxed it comes out warm by reason of its rarefaction theophrastus physics six are twenty four comma twenty six an exmenes of meletus son of eurystratus a companion of an exmander agrees with him that the essential nature of things is one and infinite but he regards it not as indeterminate but rather determinate and calls it air the air differs in rarity and in density as the nature of things is different when very actuated it becomes fire when more condensed wind and then cold and when still more condensed water and earth and stone and all other things are composed of these and he regards no motion as eternal and by this changes are produced hippolytus philosopher man seven an ex men he himself a melasian son of eustratus said that the infinite air is the first principle from which arise the things that have come and are coming into existence and the things that will be and gods and divine beings while other things are produced from these and form of air as is follows when it is of very even consistency it is imperceptible to vision but it becomes evident as the result of cold or heat or moisture or when it is moved it is always in motion for things would not change as they do unless it were in motion it has a different appearance when it is made more dense or thinner when it is expanded into thinner state it becomes fire and again winds are condensed air and air becomes cloud by compression and water when it is compressed further and earth and finally stones as it is more condensed so that generation is controlled by the opposites heat and cold and the broad earth and the moon and all the rest of the stars being fiery bodies are supported on the air by their breath and the stars are made of earth since exaltations arise from this and these being accentuated become fire and of this fire when it is raised to the heavens the stars are constituted there are also bodies of an earthly nature in the place occupied by the stars and carried along with them in their motion he says that the stars do not move under the earth as others have supposed but around the earth just as a cap is moved about the head and the sun is hidden not by going underneath the sun but because it is covered by some other higher parts of the earth and because of its greater distance from us the stars do not give forth heat because they are so far away winds are produced when the air that has been attenuated is set in motion and when it comes together and is yet farther condensed clouds are produced and so it changes into water and hail is formed when the water descended from the clouds is frozen and snow when these being yet more filled with moisture become frozen and lightning when clouds are separated by violence of the winds.
Seven VIIINARRATOR
26:49
For when they are separated, the flash is bright and like fire, and a rainbow is produced when the sun's rays fall on compressed air, and earthquakes are produced when the earth is changed yet more by beating and cooling.
Graham SkidmoreGUEST
5:27
And so it can be real easy to say, "Oh, I could have done that, I could have figured that out," et cetera, et cetera.
Graham SkidmoreGUEST
5:31
And so anyway, so I think that this is where-- this is also where the focus on taking a step back and saying, okay, look, forget about taking the approach of incremental optimization within broken systems and how do we just improve margins and make things a little better, and saying, okay, let's just say we were to start all over, right? Let's take a first principles approach and think about what the best case scenario is if we were to be building this company out of our garage right now, and starting from that landscape and that perspective.
Graham SkidmoreGUEST
5:57
And then from there you can start to figure out where, you know, you need to reshuffle people, where you need to insert technology, how you get them to work together.
Graham SkidmoreGUEST
6:04
And look, and there's gonna be a lot of-- and I think that this is where there's gonna be some tough moments where businesses gotta realize, oh crap, we didn't-- we recognize our business model, but we weren't close enough in understanding enough our business operations.
Lester NareHOST
5:24
We're going into the fall season, and there's a couple of different big scientific events that are happening, and so we're just gonna do a very light overview of what those look like.
Lester NareHOST
5:37
So unlike some of our normal deep dives, we're just gonna cover the surface, but still keep it focused on the science, because this is From First Principles.
Lester NareHOST
5:47
[upbeat music]So we're beginning the fall season in science, and one of our main events that we are excited for, some may say it's the Ballon d'Or-
Krishna ChoudharyHOST
6:13
Mm-hmm

15 MINS LATER

Krishna ChoudharyHOST
21:38
Ooh, look at that.
Lester NareHOST
21:40
[laughs] We did a huge revamp on the website.
Lester NareHOST
21:44
You can see our platonic solids on the home page now doing our animation around From First Principles.
Lester NareHOST
21:51
But I wanted to take this opportunity to, uh, identify, because we have so many new listeners-
SamHOST
2:34
Okay, so what's actually going on there? Because that's not a normal investment decision.
SophieHOST
2:40
It's first principles thinking.
SophieHOST
2:41
He looked at rockets and asked why they cost so much.
SophieHOST
2:45
And the answer was the manufacturing process, not the materials.
Eric RiesGUEST
37:26
It's impossible to experiment with everything.
Eric RiesGUEST
37:28
You must have some first principles.
Eric RiesGUEST
37:30
There must be some beliefs that you have that are not subject to empirical verification that you believe in anyway.
Eric RiesGUEST
37:37
And I think I really didn't appreciate how important that was and certainly didn't make it clear enough in my earlier writing that this is a necessary part of the process.
Eric RiesGUEST
37:45
Now, that doesn't mean you never change your mind.
Eric RiesGUEST
37:47
Of course you do.
Eric RiesGUEST
37:48
Even with first principles, you can change your mind.
Eric RiesGUEST
37:50
But it's important to recognize that that kind of change, a change of values, a change of vision, a change of who you are as a person, That is not happening.
Peter HofstraGUEST
2:23
What's the first principle? What is it that we take to apply here? But it's a unique circumstance.
Peter HofstraGUEST
2:28
So, you know, it's not just blindly let's stand the same rules in every time.
Peter HofstraGUEST
2:32
What is it that this situation needs to get to the greatest outcomes possible? So I think there's some principles that come from spending time in science around, you know, problem solving and first principles and that kind of thing.
Peter HofstraGUEST
2:44
But I think it's also been very helpful to get an understanding of the physical world.
Peter HofstraGUEST
2:47
I mean, there's only so many ways atoms can interact, right? When your covalent bonds, hydrogen bonds, ionic bonds, right? And how do they form and what gets prioritized? So when you're seeing ideas in the real world, I have found it very helpful to have that bit of background and say, can this work? What are the challenges here? If we're trying to solve energy storage, our lead-acid battery is a good idea.

21 MINS LATER

Peter HofstraGUEST
24:28
And so we are looking, say, to invest and say, by definition, that investment is intended to be worth more in the future, right? And so, again, we can talk about other ways to allocate capital things where maybe there is a very different expectation.
Peter HofstraGUEST
24:40
Those things are great, but keeping it, you know, to that sort of arena.
Peter HofstraGUEST
24:44
Yeah, we do always look at, you know, what are the future economics of this business likely to be? So it's all about what is the business model? And it's, again, there's generic elements to this first principles.
Lester NareHOST
1:57
By the end of this episode, you will be able to look at the graphical abstract from the paper and understand what exactly is happening.
Lester NareHOST
2:07
As always, we are going to talk about the science from the ground up today because this is From First Principles.
Krishna ChoudharyHOST
2:28
Multiple sclerosis, leukodystrophies, and periventricular leukomalacia in premature infants.
Krishna ChoudharyHOST
2:36
These are all not actually obscure conditions that are buried in the back of some medical textbook, okay? This isn't like house an episode where it's like some weird thing.

1 HR 25 MINS LATER

Krishna ChoudharyHOST
87:18
Yeah, it's, I mean, incredible amounts of genetic engineering, bioengineering to get this kind of access, you know? And also just, it's just standard, like, scientific method.
Krishna ChoudharyHOST
87:30
It's,
Lester NareHOST
87:31
one would say they did it from first principles.
Lester NareHOST
87:34
Yeah.

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