Fentanyl
MedicationWikipedia
261
MENTIONS
186
EPISODES
157
PODCASTS
Search complete. 261 mentions across 186 episodes found for "Fentanyl".
Oct 27, 2026
Bobby CapucciHOST
What's up, everyone, and welcome back to the program.
Bobby CapucciHOST
In this episode, we're going to keep the conversation about El Chapo's sons, the Los Chapitos, and how they built a fentanyl empire that poisoned America.
Bobby CapucciHOST
Today's article is from Reuters and the headline, Special Report, How El Chapo's Sons Built a Fentanyl Empire Poisoning America.
Bobby CapucciHOST
This article was authored by Drazen Jorjic.
Bobby CapucciHOST
In January 2017, days after Mexico extradited the notorious drug trafficker Joaquin El Chapo Guzman to the United States, local cops in his home state of Sinaloa fell under attack.
Joe BartolozziHOST
It could be laced with so many different things.
Joe BartolozziHOST
Fentanyl could be in your cocaine.
Joe BartolozziHOST
You could fucking overdose and die.
Joe BartolozziHOST
Cocaine is also absurdly addictive.
Mercedes DodgeHOST
But here's the message I don't want lost with this slide is that fear of precipitated withdrawal should not be treating the opioid use disorder.
Mercedes DodgeHOST
Fentanyl changes how thoughtfully we can initiate buprenorphine.
Mercedes DodgeHOST
It does not make buprenorphine unusable.
Mercedes DodgeHOST
Just know the clinical pearl over all the old rules of wait 12 to 24 hours no longer apply.
Brad CartnerHOST
It was fentanyl.
Brad CartnerHOST
And they didn't even know it.
Brad CartnerHOST
Fentanyl is 50 to 100 times more potent than heroin.
Brad CartnerHOST
A few grains, barely visible to the naked eye, well, that can kill you.
Brad CartnerHOST
Cartels, they started to figure this out around 2013, 2014.
Brad CartnerHOST
At first, they mixed it into the heroin to stretch their supply, to make it stronger, to keep people hooked.
Brad CartnerHOST
But then they realized something else.
Brad CartnerHOST
Fentanyl is cheaper to make than heroin.
speaker_0HOST
It's a nice kind of sedative to keep the patient arousable and cooperative.
speaker_0HOST
Fentanyl, like all opiates, mu opioid receptor agonist.
speaker_0HOST
This is a potentiator.
speaker_0HOST
potent analgesic.
speaker_0HOST
But common downsides are going to be bradycardia is the main one.
speaker_0HOST
It also can cause hypotension, but bradycardia is the main one.
speaker_0HOST
Fentanyl.
speaker_0HOST
is this analgesic base layer, right? It's a great workhorse for analgesia in the mechanically ventilated.
Molly AllenHOST
Can you imagine going to a party and being like, do you want to do a line? No.
Molly AllenHOST
Fentanyl, A, and no. It's just so 80s.
Molly AllenHOST
It's very 80s.
Molly AllenHOST
I can't even imagine being in a party like that.
Jake StuckiGUEST
And what happens is there's a little bit more detail to the mechanism of action.
Jake StuckiGUEST
Fentanyl, after it binds the opioid receptors, specifically the mu opioid receptor, It causes the GTP exchange with GDP on G proteins, if you think back to our biochem days.
Jake StuckiGUEST
And then through a process of adenylate cyclase, cyclic AMP, and calcium, it basically results in nerves being less excitable.
Jake StuckiGUEST
And so when the nerves are less excitable, less pain is transmitted.
Joe BartolozziHOST
It could be laced with so many different things.
Joe BartolozziHOST
Fentanyl could be in your cocaine.
Joe BartolozziHOST
You could fucking overdose and die.
Joe BartolozziHOST
Cocaine is also absurdly addictive.
Tom MulcairGUEST
My favorite was fentanyl.
Tom MulcairGUEST
I mean, Canada was the source of the fentanyl going into the United States.
Tom MulcairGUEST
Fentanyl, by the way, is one of the most horrific drugs ever to make it to the market.
Tom MulcairGUEST
But we were responsible for 0.4% of the fentanyl in the United States.
Tom MulcairGUEST
It had nothing to do with us.
Tom MulcairGUEST
My favorite was fentanyl.
Tom MulcairGUEST
I mean, Canada was the source of the fentanyl going into the United States.
Tom MulcairGUEST
Fentanyl, by the way, is one of the most horrific drugs ever to make it to the market.
Tom MulcairGUEST
But we were responsible for 0.4% of the fentanyl in the United States.
Tom MulcairGUEST
It had nothing to do with us.
176 more episodes mention Fentanyl.
Create an account to see the whole feed, search across every transcript, and follow the entities you care about.