Fecal microbiota transplant
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Search complete. 72 mentions across 15 episodes found for "Fecal microbiota transplant".
Sep 17, 2026
Ben GreenfieldHOST
I did do a- as, as recommended by the physician who prescribed it to me, a two-week course of rifaximin antibiotic first to basically clean the slates.
Ben GreenfieldHOST
I did a pre- and post- essentially the equivalent of like a food allergy panel, pre three-month, post three-month, and it, like my food allergy panel did go from being lit up like a Christmas tree to being pretty even keel with just a few things left after doing the antibiotic plus the FMT.
Ben GreenfieldHOST
And then the reason I bring that up is when you were talking about like putting healthy bacteria into an unhealthy terrain, I think what some doctors are doing, at least based on my personal experience, is just like nuking the entire gut with an antibiotic and then following that up with something like, like an oral capsule.
Josh DechGUEST
Yeah, I mean, that's, there's three ways to give an FMT.
Josh DechGUEST
There's one, the capsules like you use.
Josh DechGUEST
I think, uh, Dr. Steven Gundry calls them crapsules lovingly.
Josh DechGUEST
The next is actually a colonoscopy, where you are under anesthesia.
Josh DechGUEST
There's gastroenterologists that go in clean and physically transplant, oops, they physically transplant way up in the bowel.
SamHOST
And so, in case you're unaware, Jack probably, if something has a microbiome, if it can be sequenced, he's probably sequenced it.
SamHOST
And so we are absolutely thrilled today to sit down with him and to pick his brain on all things FMTs.
SamHOST
More on what that abbreviation means in just a minute, so...
SamHOST
Jack, how are you doing today? And thank you so much for joining us.
SamHOST
Lovely to be here, and I'm doing well.
JuliaHOST
Yeah, it's good to have you on.
JuliaHOST
This episode might not be safe for work with FMTs, but we'll chat about that a bit more later, right?
Jack GilbertGUEST
Depends where you work.
Robert SilverGUEST
They always provide two tests.
Robert SilverGUEST
One test, they developed an AI app to to analyze the microbiome, and then to suggest five different pathways, including nutrition, supplements, good water, exercise, and detoxification, minus FMT.
Robert SilverGUEST
And really, FMT is great, and it definitely has a time and a place.
Robert SilverGUEST
But I think the things that we do at home The things that we do for our pet every day, the things that we've been promoting even long before we knew about the microbiome as being healthy, in a way, this process kind of reinforces that healthy approach to life and then gives them feedback to show them that it's actually improving things.
Robert SilverGUEST
So I'm excited about that.
CharlotteHOST
So they did a blinded randomized control trial in dogs with chronic enteropathy.
CharlotteHOST
So more than sort of three weeks of intestinal diarrhea and they basically allocated them to either having a fecal microbiota transplantation or to just a standard treatments group where they basically just had a diet change so it was mostly looking at dogs with like a food responsive enteropathy and basically they just use fresh fecal material from donor dogs and put it in via a rectal enema and they just did one they just did a single retention enema and that's all they did And basically, with the results, it said, this study did not demonstrate a clear clinical benefit for adjunctive fecal microbiota transplantation by a single retention enema in dogs compared to diet change alone.
CharlotteHOST
So they said in those patients, it actually doesn't really make that much difference.
CharlotteHOST
But they have said that there was only a small sample size, so they can't exclude that, you know, there's bias or type 2 error, etc.
Josh DechHOST
A lot of them are dead on the shelf.
Josh DechHOST
How is it next to an FMT or a live microbiome, like a physical transplant? For those of you, FMT means fecal microbiota transplant.
Josh DechHOST
You literally take the microbiome from a healthy person, insert it, or however you end up getting it there through enema or capsules to somebody else.
Josh DechHOST
But when you say you can bring these things back...
Muyiwa AwoniyiGUEST
There's no microbiome test to order.
Muyiwa AwoniyiGUEST
There's no FMT or fecal microbiota transplant indication for PSE UC yet.
Muyiwa AwoniyiGUEST
And nothing in the mouse data should alter guideline surveillance intervals.
Muyiwa AwoniyiGUEST
What changes is the index of suspicion and where we point our colonoscope.
Matt KirshenHOST
So in this new trial, scientists gave 15 adults with peanut allergies capsules containing fecal microbiota, essentially carefully processed communities of gut bacteria extracted from healthy donors' poop.
Matt KirshenHOST
This technique called fecal microbiota or fecal matter transplant, FMT, is a promising therapy that aims to reset the gut microbiome.
Matt KirshenHOST
In human trials, it has helped alleviate depression, inflammatory bowel disease, type 2 diabetes, and more, though it does not work for everyone.
Matt KirshenHOST
There is a link there to another story about how this does not always help.
Matt KirshenHOST
So now we have human data suggesting that it may be a help in a similar way.
Katie NovotnyGUEST
The trial
Matt KirshenHOST
conducted at Boston's Children's Hospital was a phase one open label study that prioritized safety and determining whether FMT was an effective way to address peanut allergies.
Matt KirshenHOST
At the start, participants were highly sensitive.
CarlyHOST
You're destroying that gut, yeah.
CarlyHOST
So how about we just, just for the fun of it, not give them antibiotics for a month, give them FMT for a month, 'cause it's so easy to do now.
CarlyHOST
You got capsules.
CarlyHOST
It's like, here.
Judy MorganGUEST
90%Or more.
Judy MorganGUEST
Of the pets that would come in that had these chronic problems, we would make those simple changes.
Judy MorganGUEST
Like I wasn't even doing FMT then 'cause it, we didn't have it-
SherryHOST
Mm-hmm
Josh DechHOST
So here's what we're looking at.
Josh DechHOST
I want to talk about what FMT is actually good for.
Josh DechHOST
Because I get asked this a lot.
Josh DechHOST
People are like, well, I want to try it for my Crohn's or my colitis or my whatever.
Josh DechHOST
Is it worth doing? Let's look at what the research says first.
Josh DechHOST
We know that what's actually approved currently by the FDA within the United States, FMT is approved for recurrent C. diff infections.
Josh DechHOST
Well, if you don't know what C. diff is, Clostridium difficile, it's a nasty bacterial infection that can be lethal.
Josh DechHOST
It's extremely contagious, it is highly inflammatory, and it's basically death by diarrhea.
Mark HymanHOST
And that, that also may be an issue.
Mark HymanHOST
They're actually doing fecal matter transplants or what we call FMTs or, or basically poop transplants, um, in, in people with, um, uh, autism, uh, with, with ADHD, and it's pretty amazing.
Mark HymanHOST
So, um, I think kids who've had a lot of antibiotics, you know, uh, have a higher risk of getting, getting ADHD.
Mark HymanHOST
So we know the gut plays a huge, huge role in, in the overall regulation of the brain and mood, cognitive function.
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