Extracellular vesicle

Um, and then I was lucky to get a, a nice grant from the Chan Zuckerberg Initiative that allowed us to do some high-risk kind of experiments.

And, um, we sort of hypothesized that since Oc was being secreted in this virus-like particle that was generating these extracellular vesicles, uh, there was some data supporting, uh, a role for these e- for a, for a extracellular vesicle type in, uh, secreting these toxic proteins that are involved in neurodegeneration as almost like a, you know, quick garbage disposable way of getting that toxic protein out of the cell.

So, so that's how the, this st- this latest story started, was just sort of thinking, "Okay, maybe Oc's involved," not really-

Mm

So tell us what they are.

Yeah.

So extracellular vesicles.

So exosomes are a certain type of extracellular vesicle, and so cells re-release these membrane-bound packets of proteins, and there's a whole bunch of different kinds, different sizes, different biogenesis, different origins of the membrane.

You see? So these are naturally occurring positive effects in the production of bone, right? It's just another event that these caveolae are functioning in.

I want you to know that extracellular vesicles, now what do they look like? They're surrounded by their own membrane, right? Yeah? And they're released when they are released from KVOLA.

So not just from porosomes, no.

So the EVs transport, and I was mentioning this before, messenger RNA, microRNA, which would be an epigenetic phenomena, controlling translation, right? Not just translation, but among lipids and various other proteins.

And those EVs transporting all of this molecular event through a caveola will be sending it to recipient cells.

And when it sends it to recipient cells, it does so in a dose-dependent manner, thus potentiating the downstream effects.

So it turns out there's two types of EVs, extracellular vesicles.

And that's based entirely really on the route of release.