Eric Topol

Study identifies mitochondrial dysfunction as the cause of long COVID fatigue.

You see here from Eric Topol as well, highlighting a number of studies looking at the microbiota and mitochondrial dysfunction as well.

And way back, even as far back as April of 2020, we made the conclusion based on the studies that reactive oxygen species in the mitochondria was the result of ACE2 not being functional because of the virus.

And because of that, you had an increase in angiotensin 2 and a decrease in angiotensin 1,7.

But the first self-driving Tesla that runs into a stop sign, you know, people lose their minds, right? Because the very low tolerance for this sort of machine error, even though the rate of error is so much smaller, right? And in fact, it'd be really interesting for your viewers to go look at this.

You know, Eric Topol, who's quite a renowned doctor and scientist here in the U.S., he, along with other physicians, just kind of penned a letter, and I can't remember if it was the New England Journal of Medicine or somewhere else, but had been essentially saying, like, the data around automated cars... is so good that if it was a drug, we would be out of our minds to not prescribe this drug everywhere because we're reducing deaths by 95%.

If we wanted to reduce car deaths by 95%, we essentially, everybody stopped driving, get an automated

car.

They also found that 25% of people were taking omega-3, the fish oil, or krill oil supplements, and nearly 20% were taking herbal supplements like ginseng.

Now, Dr. Eric Topol, who's a cardiologist and the founder of the Scripps Research Translational Institute, says there are good reasons to take the supplements, maybe to treat a nutrient deficiency or to prevent birth defects.

But he says most of these are a waste of money, and it's a lot of money.

The global supplement industry valued at $228 billion, with a B.

Okay.

I'm Eric Topol, and this is Ground Truth.

Thrilled that you're joining us today.

I have the real delight to, um, have this discussion with, uh, Marios Georgakis at, uh, the University of Munich, uh, who is a physician scientist, actually a neurologist who studies atherosclerosis, genomics, uh, particularly the cerebrovascular, but he certainly is tuned into the coronary and atherosclerosis anywhere in the body.

JAMA's latest episode of JAMA Plus AI Conversations has a fascinating conversation with Drs.

Roy Perlis and Eric Topol.

They discuss the science of aging, how to think about AI-enabled medicine, including what it will take for AI to move medicine from reactive to predictive.

They also talk about why some well-validated imaging AI remains underused while the large language models have spread rapidly and whether AI is actually giving clinicians more time with patients.

[on-hold music] Welcome to JAMA+ AI Conversations.

I'm Roy Perlis, editor-in-chief of JAMA+ AI, and I'm pleased to welcome today's guest, Dr. Eric Topol, cardiologist and founder and director of the Scripps Research Translational Institute, and one of those people who consistently ends up on the top 25 list of influential people in medicine.

Dr. Topol's spent a couple of decades now writing about where medicine is going in books like "The Creative Destruction of Medicine," "The Patient Will See You Now," "Deep Medicine," and most recently, "SuperAgers: An Evidence-Based Approach to Longevity," which came out last year and has been on bestseller lists pretty much since then.

He also writes Ground Truth, a widely read online publication, so he's busy.

I don't know that many people are talking about this yet, but I do think over time it will become the main agenda.

It's a lot to look forward to.

Dr. Eric Topol, thank you for talking with us about aging, about AI, about predicting the future.

To our listeners, you can find links to Dr. Topol's recent work in the episode notes.

... which kind of undercut the story.

But anyway, I, listen, I think it's great that he's out there, just like I think it's great that, um, Matt Kaeberlein's out there and, um, Eric Topol.

You need, this is one thing that people really need to understand about health and longevity in the online communities.

In science, in medicine, and I observed this in the, in the world of skateboarding and, and action sports, you need a community, uh, that represent the sort of different extremes, right? In skateboarding we have our Tony Hawk, we had our, my friend Danny Way, who gr- jumped the Great Wall of China.