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Eric D Scheeff
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Sep 10, 2026
Building a Roadmap to Treat a Rare Neurodevelopmental Condition
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11:16Daniel LevineHOST
How did you decide where to focus limited resources? And how did you prioritize what to build first versus what to wait?

Eric ScheeffGUEST
Yeah, it's a really important question because as a nonprofit, resources are always limited.

Eric ScheeffGUEST
And what we did is we looked at the landscape holistically together with our SAP, our Scientific Advisory Board.

Eric ScheeffGUEST
And then we thought backwards from the final goal of getting into clinical trials.

Eric ScheeffGUEST
And we asked, you know, what's missing? What would make the biggest impact? And so one of the things we did early on was create patient cell lines that can, these so-called iPSC cell lines that can be grown into neurons in a dish and other cells of interest.

Eric ScheeffGUEST
And lines were out there and there was a characterized model for cleavage neurons grown in dishes.
8 MINS LATER
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20:15Daniel LevineHOST
Are there other therapeutic approaches that iDefine's exploring or considers promising for cleavage syndrome?