Epithelial–mesenchymal transition

Remodeling the tumor microenvironment.

The study’s pathway analyses showed enrichment in biological processes related to extracellular matrix organization, collagen metabolism, integrin signaling, epithelial-mesenchymal transition, EMT-associated pathways.

These pathways are commonly associated with tissue remodeling, cell migration, and tumor invasion.

The authors propose that MECs may help create a microenvironment that facilitates cancer cell movement and metastatic spread.

And I was thinking about it when I was given the last lecture.

And so this is what I collected from that and now transforming it into kind of like an EMT, right? Into just like one clear statement.

Now think about what I'm going to say relative to the regulation of cells moving from being epithelial to being mesenchymal, which then means they're moving through essentially a de-differentiation.

They're no longer really epithelial cells.

You may be able to measure the marker's quantity.

That may go up and down.

And you might say, oh, when it increases, we see, for example, an EMT event.

But that doesn't mean that was necessarily associated with that quantitative change.

So what we discuss is the endothelial mesenchymal transition.

The EMT.

Okay? That's how we start looking at transformed cells that become cancer cells.

So let's get into this discussion.

Remember, succinate dehydrogenous, and on and on and on, which is actually complex to an electron transport channel.

Stuff you should have in your mind.

So remember, when you start with acetyl-CoA, you're synthesizing all these other carboxylic acids, right? So all of them are used as acylation tools to control gene expression, which is involved in morphological and such things as EMT transitions.

Cancer cells.