Entrectinib

Since then, a number of different pills have been developed.

Entrectinib is a drug that followed, um, and there are next generation drugs that I'm sure we'll speak about today.

today.One of the things that's interesting about targeted therapy is in many situations, including EGFR and ALK, you see responses in the brain, which is kind of new in oncology, and even we started to see people holding off with local therapy, radiation to the brain, and using these systemic agents.

They were so effective.

I should say that Pemetrexed-containing chemo can work very well, um, for many lung cancers, um, lung adenocarcinomas.

But we also said, "Did we miss something?" And so during the chemo, we sent, um, her biopsy for more comprehensive testing, and next-generation sequencing returned positive for a ROS1 fusion, the most common kind actually called CD74 ROS1.

Because of that, we knew we had this in our back pocket, um, so that when it was time for her to switch therapy, we then switched her to Entrectinib, which is one of the first-gen pills that I mentioned earlier.

On the original clinical trial, it had a really wacky name.