Endocannabinoid system

The excretory systems.

And we also have an endocannabinoid system.

And the endocannabinoid system is something that... we never learn about in medical school and nursing training and health care training.

It's something that's put to the side.

And we've known about the endocannabinoid system for

over 20 years.

Let me just clarify what this means, Ian, if you don't mind.

Every cell in your body, apart from red blood cells, contain receptors for cannabinoids.

The endocannabinoid system is unique.

Most neurotransmitters are synthesized in the presynaptic neuron, released, and bind to the postsynaptic neuron.

Endocannabinoids travel backwards.

Backwards.

Yes.

Scenario 5.

Focus on concepts.

Endocannabinoids.

On this episode, we speak with Ondar Albayram from the Medical University of South Carolina, whose work has explored the role of the endocannabinoid system in brain aging and neuroprotection.

His research has investigated how THC and endocannabinoid signaling influence cognitive function and neuroinflammation, with implications for understanding and potentially treating age-related cognitive decline.

Welcome to the Epigenetics Podcast from ActiveMotif.

So can you tell us about the work you did there?

Yeah, yeah, Stefan.

Let me tell briefly about what is endocannabinoid, you know, what is cannabinoid and endocannabinoid system.

Just briefly, endocannabinoid system is a kind of discovered actually when the scientists interested active ingredient of the Mariana plant.

cannabis sativa, in other words, and back to 1950s, it eventually cannabis named the whole system.

Caroline Redmond-Lusher, brought to you by the words cannibal...

Endocannabinoid.

So let's just talk about hemp for a minute.

Hemp literally interacts with a system that we all have, all animals have called the endocannabinoid system.

It's actually called the endocannabinoid ohm now because they have incorporated the entire gut microbiome as part of this system.

This system is the master system in every animal's body.

We just deal with the kidneys or hormones.

We have an issue in the endocrine system, so we just deal with that.

When we do that, we never get back to homeostasis because we're ignoring the endocannabinoid system.

So when we have a healthy endocannabinoid system, we're producing endocannabinoids.

Definitely.

So long before humans ever cultivated a single crop, our bodies evolved the endocannabinoid system, endogenous meaning originating inside the body.

Right.

And this system runs on two primary receptors, doesn't it?

You'd be paralyzed.

Forgetting is just as vital to human survival as remembering.

The endocannabinoid system acts as a biological filter.

It prunes away the irrelevant noise so you can actually function.

Or is this just a social experiment or personal experience?" [chuckles]

Before we get into exercise, I think the biggest thing for both of us was something that I was never actually heard about before, was the endocannabinoid system, because I didn't know that we had one.

Same.

Same.

And when I first came across it, I actually stopped reading for a second because I thought, "How have I never heard about this? Like, who's keeping this information from us?" And every single one of us is born with something called the endocannabinoid system.

So from birth, straight out of the womb, it's there, right? [chuckles] It's one of the body's natural communication systems, and it helps to regulate things like your mood, your appetite, sleep, memory, stress, your pain, and even how you respond to exercise.

And what's really fascinating is that our bodies naturally produce its own compounds called endocannabinoids, which interact with our ca- endocannabinoid receptors in our body throughout the day.

Side top.

MOTS-c reduced the cellular response to hypoxic stress in the TBI model, making it particularly interesting for neurological conditions involving impaired oxygen delivery or mitochondrial dysfunction.

Then we have neuroinflammatory modulation, whereby MOTS-c reduced inflammatory signaling after TBI, including downregulation of macrophage migration inhibitory factor, known as MIF, while influencing retrograde endocannabinoid signaling.

Then we have neuronal protection, where experimental findings suggest reductions in molecular damage and cell death following neurological injury, giving MOTS-c a broader neuroprotective rationale.

We have memory and cognitive resilience, whereby MOTS-c-related research has shown improvements in memory formation and consolidation and protection against inflammatory or amyloid-associated memory impairment.