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Elamipretide

Elamipretide

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Search complete. 99 mentions across 34 episodes found for "Elamipretide".

Sep 13, 2026

Joshua SmithHOST
27:07
My phone's all like just trying to minimize your EMF exposure, you know, if you're able to.
Joshua SmithHOST
27:14
And then that's one of the reasons why I made the decision of, you know, going hardcore with SS 31, MOTC and running these things daily to hopefully rebuild that mitochondria in the inner ear.
Joshua SmithHOST
27:29
So if I can, you know, solve the tinnitus, solve the, get back some of that hearing, you know, I'll keep everybody updated on that.
Joshua SmithHOST
27:39
But the, you know, that shit is like shit we can all deal with.
Sal Di StefanoHOST
19:49
Not a lot, but I definitely notice I get a little leaner.
Sal Di StefanoHOST
19:52
There's another peptide in this category that works differently called SS-31.
Sal Di StefanoHOST
19:57
SS-31 operates, uh, differently than Mot-C, so it's totally different.
Sal Di StefanoHOST
20:02
Started SS-31, I think I love it.
Adam SchaferHOST
20:04
Really?
Sal Di StefanoHOST
20:04
Yeah, dude.
Adam SchaferHOST
20:24
What, mechanistically, are they doing the same thing? They doing something different?
Sal Di StefanoHOST
20:27
Different to the mitochondria.
Mike NassifGUEST
35:09
Those would probably be kind of the most common I would say that I'm using with people.
Mike NassifGUEST
35:12
SS-31 as well.
Mike NassifGUEST
35:14
Um, for me, the first needle-- RAD-0 is really one that I would say is like a big needle mover, um, I, in my opinion at least.
Mike NassifGUEST
35:24
Really at the f- at the start of a contest prep, once there's an initial uptick in hunger and I see that like, you know, it's, it's not gonna crush someone's appetite because I do always want there to be some hunger present.
Mike NassifGUEST
35:59
Um, and usually I will honestly try and escalate that per hunger cues for the individual, um, 'cause again, every single time I do that I'm seeing further fat loss happen without having to change any other variables.
Mike NassifGUEST
36:10
So, um, again, for me I, I will introduce it as early on as I can once there's hunger cues telling me that it's not gonna, you know, wreck someone's appetite with bringing that in.
Mike NassifGUEST
36:20
Um, SS-31, um, I like using this.
Mike NassifGUEST
36:26
H- honestly, going back to even prior to a contest prep, I like introducing SS-31 in almost pre-prep phase, maybe like, you know, before we get start that kind of like initial fat loss happening.
Chad PrusmackGUEST
34:25
Can increase VO2 max significant percentages, very good for performance.
Chad PrusmackGUEST
34:30
So MOTS-c is a- another one, and then the most recent one we've been using is SS-31, which seems to be something that by changing the confirmation of that cardiolipin moiety, it gives you more bang for your buck.
Chad PrusmackGUEST
34:47
So by the change of how you're delivering electrons, you're delivering more ATP per unit transport.
Eric GordonHOST
34:57
Yeah.
Chad PrusmackGUEST
39:04
And so someone who wants to run a marathon, MOTS-C.
Chad PrusmackGUEST
39:08
Someone who is sore in the morning and needs better recovery, BCP 157, tesamorelin, ipamorelin, sermorelin, w- you know, any of those things.
Chad PrusmackGUEST
39:20
But what I've been doing a lot of now is SS-31, NAD are probably two of what I would consider, at least in the, the near term, seems to be quite healthy, good responses, again, cognitively, emotionally, and the hormones obviously are important to restore.
Eric GordonHOST
39:41
Right.
Jim BrownHOST
16:58
Again, MOTC, I take MOTC about twice a week now.
Jim BrownHOST
17:02
And that's to keep that maintained higher energy level that I've gotten from MOTC and from mitochondrial health, metabolic health, all over, you know, just overall.
Jim BrownHOST
17:12
DSS-31, same.
Jim BrownHOST
17:13
I'm at a milligram a day until further notice and see if that has a, it's reflected in my blood work, but, you know, just really bought into the science of that.
Jim BrownHOST
17:24
The DSIP, I'm going to go back to.
Hunter WilliamsHOST
104:23
Probably will end up making its way into the research world here pretty soon.
Hunter WilliamsHOST
104:26
Seems to be kind of like an oral version of SS-31 is the best way to simplify it.
Hunter WilliamsHOST
104:32
And that's been studied in humans in Japan, safe and everything.
Hunter WilliamsHOST
104:36
And so I think that's...
Priscilla HetrickHOST
8:05
So it helps regulate the mitochondrial production of the reactive oxygen species to protect the cellular membrane and participate in an anti-inflammatory pathway.
Priscilla HetrickHOST
8:15
So when I thought of this, I thought of, so like SS 31, which is a peptide goes in and helps heal that membrane, right? Well then think of taurine that goes in the already repaired cell to make it function better.
Jason HetrickHOST
8:34
Makes sense.
Priscilla HetrickHOST
8:35
Does that make sense?
Chris DuffinGUEST
73:11
So that's a really good base level, and then the next cycles, we might look at SLU-PP.
Chris DuffinGUEST
73:17
Or again, this candidate would probably go with S, also SS-31, which is gonna help repair the cardiolipin in the electron transport chain, which is probably causing some of the brain fog, lack of ATP reaching the brain, those energy crashes in the afternoon based on the the avatar I, I gave you, right? The, the, um, that's where SS31 would do.
Chris DuffinGUEST
73:41
SLU or MOTC might be the one that comes in and revamps and pushes us a little bit harder during performance periods and helps further with insulin sensitivity if we've got some of those issues, and just restoring the metabolic, restoring the metabolic function without having to go down the GLP route.
Chris DuffinGUEST
74:01
Let's say the person's 40, 50 pounds overweight, we might run a cycle of the GLP or something somewhere in there if needed, right? So that would be a base level.
Todd CollinsGUEST
6:02
energy?[chuckles] Absolutely, Amy.
Todd CollinsGUEST
6:05
And that brings us to mitochondrial peptides like MotC and SS-31.
Todd CollinsGUEST
6:10
You know, I remember a lab colleague of mine years ago who was analyzing cellular endurance, and they kept running into metabolic bottlenecks where the cells simply ran out of steam under stress.
Todd CollinsGUEST
6:20
When they introduced mitochondrial signaling peptides like MotC, the cellular power plants, the mitochondria, were able to optimize glucose usage and maintain energy output under heavy load.
Todd CollinsGUEST
6:31
MotC acts like a smart grid controller for your cellular power generators, while SS-31 acts like a protective shield against oxidative stress inside those same mitochondria.
Amy AndrewsHOST
6:42
Wow.
Amy AndrewsHOST
6:42
So while MotC optimizes the power output, SS-31 keeps the power plant machinery from rusting out.
Amy AndrewsHOST
6:49
That explains why researchers studying healthy aging and metabolic balance are so obsessed with them.
StevesmiHOST
43:35
Did you find out that you had a little bit of a nose for this stuff and you were able to pick it up a lot quicker than other people? Because there's people that have been doing this for 20 years.
StevesmiHOST
43:48
If you go up to them and you say, hey, tell me about SS-31 or tell me about MOTC, they'd look at you like you're an alien.
StevesmiHOST
43:55
But you picked these compounds up quick.
StevesmiHOST
43:59
Did you notice, hey, I have a little nose for this stuff? Well,

31 MINS LATER

methodical.forceGUEST
74:55
You know, I like it.
methodical.forceGUEST
74:57
I like it a lot.
StevesmiHOST
74:59
And then the SS-31 and OTSI, how are you? What's your protocol?
methodical.forceGUEST
75:07
You know, I have to, you know, I have so much stuff going on.

24 more episodes mention Elamipretide.

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