Eicosapentaenoic acid
Chemical compoundWikipedia
336
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44
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37
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Search complete. 336 mentions across 44 episodes found for "Eicosapentaenoic acid".
Sep 10, 2026
EP 133: Navigating Post-Cancer Health: 4 Essential Tests for Optimal Wellness
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13:20MikeHOST
And it's such a simple blood test.
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13:23MikeHOST
It measures the percentage of EPA and DHA, your two key omega-3 fatty acids that are within your red blood cell membranes.
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13:33MikeHOST
It's not measuring what you ate yesterday.
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13:37MikeHOST
It's measuring what's actually incorporated into your cells over the past three months.
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13:42MikeHOST
This is a true tissue-level reading.
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13:45MikeHOST
And why does this matter for cancer survivors? Now, omega-3 fatty acids, specifically EPA and DHA, are potent modulators of inflammation.
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13:53MikeHOST
They're producing anti-inflammatory signaling molecules called resolvins and protectins, and they also directly influence the expression of genes involved in cell growth and cell death, or apoptosis.
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14:06MikeHOST
Now, a low omega-3 index has been correlated with higher inflammatory tone, poorer cardiovascular outcomes, cognitive decline, and here's the key here, a less favorable immune surveillance environment.
Make the Right Decision
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27:16Asa AndrewHOST
And there's two foods that go along with salmon are walnuts and flax seeds.
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27:20Asa AndrewHOST
And, of course, you get plenty of the EPA and DHA.
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27:23Asa AndrewHOST
Those are the two components of the omega-3 fats.
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27:26Asa AndrewHOST
They're so essential for brain chemistry and also hormone function and our immune system.
Supplements: What's worth it, what's just hype, and what to stop wasting money on
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15:56CassieHOST
Another one I would put in this category would be omega-3 or fish oil.
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15:59CassieHOST
So omega-3 fatty acids, particularly EPA and DHA, which you will get from fatty fish and fish oil, they have very good evidence for certain health outcomes, particularly cardiovascular health.
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16:11CassieHOST
So there's also interesting research looking at omega-3s and muscle health, as well as inflammation and recovery.
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16:16CassieHOST
But I wanna be careful here, too.
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16:21CassieHOST
The research does not show that adding fish oil to, you know, an otherwise solid lifting and nutrition program just suddenly produces, you know, dramatic muscle or fat loss or anything like that.
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16:31CassieHOST
I would put this more in that potentially useful for overall health depending on your diet category.
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16:36CassieHOST
If you regularly eat fatty fish like salmon, you may already be getting a really good amount of EPA and DHA just through your food.
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16:44CassieHOST
I personally do take fish oil simply because I don't eat fish very often, if at all.
Primo vs Mast vs DHB, Stay on TRT+ Year-Round? Mindset of a Pro Bodybuilder, Best Foods For Growth
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21:51Paul BarnettHOST
I would have chicken breast in there because it is the cheap, um, protein source that's low fat, that has, um, a pretty good amino acid profile.
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22:02Paul BarnettHOST
I would throw some salmon in there to get your DHA and EPA in.
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22:07Paul BarnettHOST
Um, you know, those are very important.
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22:10Paul BarnettHOST
Um, omega-3s, um, most people are deficient in omega-3s, so, you know, if we're not gonna supplement it, we could, we could supplement that with a fish oil pill and throw something else in there.
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25:30Paul BarnettHOST
All right, next question here.
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25:31Paul BarnettHOST
Mitchell M. said, you recently mentioned reducing your over-the-counter supplements, but you kept fish oil in.
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25:39Paul BarnettHOST
What should we look for in a high-quality fish oil supplement? How much EPA? And how much EPA do you recommend daily while enhanced? So the proper ratio of DHA to EPA is going to be two to one.
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25:56Paul BarnettHOST
And when you're buying fish oil pills, you need to actually look at how much DHA and EPA is in the fish oil pills.
Fish Oil and Your Heart: What the Trials Actually Show
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1:00AloHOST
Omicor, later called Lavaza here in the States.
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1:03AloHOST
Those were 1,000 milligram capsules combining two omega-3 fatty acids, eicosapentaenoic acid, we call it EPA, and docosahexaenoic acid, we call it DHA.
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1:14AloHOST
Doctors use them mainly to lower triglycerides.
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1:17AloHOST
which is just a type of fat in your blood.
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3:49AloHOST
And the actual absolute risk increase was small.
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3:52AloHOST
Now, one bright spot in this pile of disappointment is the JEALOUS trial from Japan back in 2007.
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4:00AloHOST
That one, you know, isolated just the EPA component, no DHA, added it to standard statin therapy, and found a 25% reduction in LDL cholesterol.
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4:11AloHOST
and a 19% relative risk reduction in major cardiac events.
#619: How Much Fish Should a Healthy Diet Contain?
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4:25Alan FlanaganGUEST
The Academy of Nutrition and Dietetics recommends about two 120 gram servings of seafood per week.
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4:34Alan FlanaganGUEST
Again, it also recommends focusing on choices that are rich in omega-3 fatty acids, EPA and DHA.
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4:41Alan FlanaganGUEST
It also then makes specific recommendations for keeping mercury levels low or eating fish that are not high in mercury.
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4:49Alan FlanaganGUEST
So those would be fish, for example, like bluefin tuna or swordfish.
53 MINS LATER
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58:19Danny LennonHOST
And therefore, the consumption is not that if you don't consume that, you must in order to be healthy.
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58:24Danny LennonHOST
In the same vein that if someone does consume those types of recommended servings that are in those typical guidelines, It does not necessarily follow that there would be a health improvement from removing them.
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58:37Danny LennonHOST
And so I think this kind of gets to those questions where two things can be held at the same time, which, again, we don't want to open the whole conversation around EPA and DHA, which we've covered in a separate episode.
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58:50Danny LennonHOST
It might be one for another day.
Every Food Hack You Need to Heal Tendons
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26:20Brodie SharpeHOST
Dietary resources such as fatty fish may be encouraged and supplementation can be considered when habitual intake is low.
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26:28Brodie SharpeHOST
Common practical strategies, they recommend approximately two to three grams of omega-3 fatty acids per day that combines EPA and DHA.
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26:40Brodie SharpeHOST
They do say though that the current evidence remains limited with respect to direct tendon or ligament specific clinical outcomes.
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26:49Brodie SharpeHOST
But as I mentioned earlier, it plays a pretty vital role in resolving inflammation that just creates a better environment, environmental optimization they call it, for supporting inflammation resolution.
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28:35Brodie SharpeHOST
They didn't talk about specifically about how much to take because I guess it just depends on your deficiency.
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28:41Brodie SharpeHOST
When it comes to calcium, they do say that 1,000 to 1,200 milligrams per day from your dietary sources and or supplementation if your intake is inadequate.
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28:51Brodie SharpeHOST
And then when it comes to omega-3 fatty acids, we're looking for approximately two to three grams of omega-3s consisting of EPA and DHA daily when dietary intake is insufficient.
B
29:06Brodie SharpeHOST
So other things to consider, it's not just all these episodes that I'm doing about making sure you're doing heavier stuff, making sure we're increasing the capacity of the tendon.
EPA vs. DHA: Fish Oil and Treatment-Resistant Depression
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1:31Richard SeeberHOST
They've also been studied for use in depression.
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1:33Richard SeeberHOST
A growing body of research, including a recent systematic review pulling from the GO-ED clinical study database, has investigated whether fish oil supplements, particularly those rich in eicosapentaenoic acid, or EPA, can be helpful for depression.
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1:48Richard SeeberHOST
To walk us through this, we have Dr. Derek Verne joining us today.
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1:51Richard SeeberHOST
He's a board-certified psychiatrist who earned his medical degree from the University of Puerto Rico and completed his psychiatric training at the University of Colorado and Emory University.
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2:14Richard SeeberHOST
And now let's take a listen to Dr. Verne.
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2:16Derick E. VergneSOUNDBITE_SPEAKER
This is Derek Vergne with the Psychopharmacology Institute's Quick Takes.
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2:20Derick E. VergneSOUNDBITE_SPEAKER
Today, I'm going to be discussing a paper from a group in China titled, Neutroceutical Eicosapentaenoic Acid EPA in Treatment-Resistant Depression, Clinical and Psychoneuroimmunity Implications.
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2:35Derick E. VergneSOUNDBITE_SPEAKER
Treatment-resistant depression remains a significant challenge in psychiatric practice.
Disease Biochemical AetiologyAdiposity-Linked Inflammatory Disease Dyslipidaemia XVIII 07Sept26 Authentic Biochemistry Podcast Dr. Daniel J Guerra
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52:14Daniel J. GuerraHOST
So even with that, all considerations, The dihomogamma linoleic acid could be a precursor to more arachidonate.
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52:22Daniel J. GuerraHOST
And in the literature since the 1980s, the reason we hear of omega-3 fatty acids in the diet, particularly EPA and DHA, is because it's been well known that the ratio of omega-6 to omega-3 is far too high in the diet.
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52:39Daniel J. GuerraHOST
Because human central nervous system lipid composition, therefore sequence of events, is typically deficient in the omega-3, not the omega-6.
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52:55Daniel J. GuerraHOST
And the dihomogamma linoleic acid is the omega-6.
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56:20Daniel J. GuerraHOST
The 24 carbon fatty acid will be desaturated and then will be essentially beta-oxidized back to the 22 carbon, and that will generate docosahexaenoid.
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56:38Daniel J. GuerraHOST
22, 6, 4, 7, 10, 13, 16, 19, where all those double bonds are, those six double bonds.
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56:46Daniel J. GuerraHOST
So you see, even the production of DHA from EPA is highly regulated.
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56:53Daniel J. GuerraHOST
And we don't have a delta-4 desaturase.
Seed Oils and Inflammation: What a New Trial Actually Found
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4:33AloHOST
Researchers aren't fully sure why, but one idea is that these fats compete for space getting incorporated into your cell membranes.
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4:41AloHOST
This doesn't mean soybean oil is dangerous, but it does mean if you're eating a lot of plant-based polyunsaturated fat, You want to make sure you're also getting enough EPA and DHA from fatty fish or a decent fish oil or algae supplement.
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4:56AloHOST
That's just good practice regardless of which oils in your pantry.
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5:00AloHOST
Now let me be straight with you about the limits of this study because I always want to give you the full picture, not just the flattering parts.
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