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Eicosapentaenoic acid

Eicosapentaenoic acid

Chemical compoundWikipedia

Search complete. 336 mentions across 44 episodes found for "Eicosapentaenoic acid".

Sep 10, 2026

MikeHOST
13:20
And it's such a simple blood test.
MikeHOST
13:23
It measures the percentage of EPA and DHA, your two key omega-3 fatty acids that are within your red blood cell membranes.
MikeHOST
13:33
It's not measuring what you ate yesterday.
MikeHOST
13:37
It's measuring what's actually incorporated into your cells over the past three months.
MikeHOST
13:42
This is a true tissue-level reading.
MikeHOST
13:45
And why does this matter for cancer survivors? Now, omega-3 fatty acids, specifically EPA and DHA, are potent modulators of inflammation.
MikeHOST
13:53
They're producing anti-inflammatory signaling molecules called resolvins and protectins, and they also directly influence the expression of genes involved in cell growth and cell death, or apoptosis.
MikeHOST
14:06
Now, a low omega-3 index has been correlated with higher inflammatory tone, poorer cardiovascular outcomes, cognitive decline, and here's the key here, a less favorable immune surveillance environment.
Asa AndrewHOST
27:16
And there's two foods that go along with salmon are walnuts and flax seeds.
Asa AndrewHOST
27:20
And, of course, you get plenty of the EPA and DHA.
Asa AndrewHOST
27:23
Those are the two components of the omega-3 fats.
Asa AndrewHOST
27:26
They're so essential for brain chemistry and also hormone function and our immune system.
CassieHOST
15:56
Another one I would put in this category would be omega-3 or fish oil.
CassieHOST
15:59
So omega-3 fatty acids, particularly EPA and DHA, which you will get from fatty fish and fish oil, they have very good evidence for certain health outcomes, particularly cardiovascular health.
CassieHOST
16:11
So there's also interesting research looking at omega-3s and muscle health, as well as inflammation and recovery.
CassieHOST
16:16
But I wanna be careful here, too.
CassieHOST
16:21
The research does not show that adding fish oil to, you know, an otherwise solid lifting and nutrition program just suddenly produces, you know, dramatic muscle or fat loss or anything like that.
CassieHOST
16:31
I would put this more in that potentially useful for overall health depending on your diet category.
CassieHOST
16:36
If you regularly eat fatty fish like salmon, you may already be getting a really good amount of EPA and DHA just through your food.
CassieHOST
16:44
I personally do take fish oil simply because I don't eat fish very often, if at all.
Paul BarnettHOST
21:51
I would have chicken breast in there because it is the cheap, um, protein source that's low fat, that has, um, a pretty good amino acid profile.
Paul BarnettHOST
22:02
I would throw some salmon in there to get your DHA and EPA in.
Paul BarnettHOST
22:07
Um, you know, those are very important.
Paul BarnettHOST
22:10
Um, omega-3s, um, most people are deficient in omega-3s, so, you know, if we're not gonna supplement it, we could, we could supplement that with a fish oil pill and throw something else in there.
Paul BarnettHOST
25:30
All right, next question here.
Paul BarnettHOST
25:31
Mitchell M. said, you recently mentioned reducing your over-the-counter supplements, but you kept fish oil in.
Paul BarnettHOST
25:39
What should we look for in a high-quality fish oil supplement? How much EPA? And how much EPA do you recommend daily while enhanced? So the proper ratio of DHA to EPA is going to be two to one.
Paul BarnettHOST
25:56
And when you're buying fish oil pills, you need to actually look at how much DHA and EPA is in the fish oil pills.
AloHOST
1:00
Omicor, later called Lavaza here in the States.
AloHOST
1:03
Those were 1,000 milligram capsules combining two omega-3 fatty acids, eicosapentaenoic acid, we call it EPA, and docosahexaenoic acid, we call it DHA.
AloHOST
1:14
Doctors use them mainly to lower triglycerides.
AloHOST
1:17
which is just a type of fat in your blood.
AloHOST
3:49
And the actual absolute risk increase was small.
AloHOST
3:52
Now, one bright spot in this pile of disappointment is the JEALOUS trial from Japan back in 2007.
AloHOST
4:00
That one, you know, isolated just the EPA component, no DHA, added it to standard statin therapy, and found a 25% reduction in LDL cholesterol.
AloHOST
4:11
and a 19% relative risk reduction in major cardiac events.
Alan FlanaganGUEST
4:25
The Academy of Nutrition and Dietetics recommends about two 120 gram servings of seafood per week.
Alan FlanaganGUEST
4:34
Again, it also recommends focusing on choices that are rich in omega-3 fatty acids, EPA and DHA.
Alan FlanaganGUEST
4:41
It also then makes specific recommendations for keeping mercury levels low or eating fish that are not high in mercury.
Alan FlanaganGUEST
4:49
So those would be fish, for example, like bluefin tuna or swordfish.

53 MINS LATER

Danny LennonHOST
58:19
And therefore, the consumption is not that if you don't consume that, you must in order to be healthy.
Danny LennonHOST
58:24
In the same vein that if someone does consume those types of recommended servings that are in those typical guidelines, It does not necessarily follow that there would be a health improvement from removing them.
Danny LennonHOST
58:37
And so I think this kind of gets to those questions where two things can be held at the same time, which, again, we don't want to open the whole conversation around EPA and DHA, which we've covered in a separate episode.
Danny LennonHOST
58:50
It might be one for another day.
Brodie SharpeHOST
26:20
Dietary resources such as fatty fish may be encouraged and supplementation can be considered when habitual intake is low.
Brodie SharpeHOST
26:28
Common practical strategies, they recommend approximately two to three grams of omega-3 fatty acids per day that combines EPA and DHA.
Brodie SharpeHOST
26:40
They do say though that the current evidence remains limited with respect to direct tendon or ligament specific clinical outcomes.
Brodie SharpeHOST
26:49
But as I mentioned earlier, it plays a pretty vital role in resolving inflammation that just creates a better environment, environmental optimization they call it, for supporting inflammation resolution.
Brodie SharpeHOST
28:35
They didn't talk about specifically about how much to take because I guess it just depends on your deficiency.
Brodie SharpeHOST
28:41
When it comes to calcium, they do say that 1,000 to 1,200 milligrams per day from your dietary sources and or supplementation if your intake is inadequate.
Brodie SharpeHOST
28:51
And then when it comes to omega-3 fatty acids, we're looking for approximately two to three grams of omega-3s consisting of EPA and DHA daily when dietary intake is insufficient.
Brodie SharpeHOST
29:06
So other things to consider, it's not just all these episodes that I'm doing about making sure you're doing heavier stuff, making sure we're increasing the capacity of the tendon.
Richard SeeberHOST
1:31
They've also been studied for use in depression.
Richard SeeberHOST
1:33
A growing body of research, including a recent systematic review pulling from the GO-ED clinical study database, has investigated whether fish oil supplements, particularly those rich in eicosapentaenoic acid, or EPA, can be helpful for depression.
Richard SeeberHOST
1:48
To walk us through this, we have Dr. Derek Verne joining us today.
Richard SeeberHOST
1:51
He's a board-certified psychiatrist who earned his medical degree from the University of Puerto Rico and completed his psychiatric training at the University of Colorado and Emory University.
Richard SeeberHOST
2:14
And now let's take a listen to Dr. Verne.
Derick E. VergneSOUNDBITE_SPEAKER
2:16
This is Derek Vergne with the Psychopharmacology Institute's Quick Takes.
Derick E. VergneSOUNDBITE_SPEAKER
2:20
Today, I'm going to be discussing a paper from a group in China titled, Neutroceutical Eicosapentaenoic Acid EPA in Treatment-Resistant Depression, Clinical and Psychoneuroimmunity Implications.
Derick E. VergneSOUNDBITE_SPEAKER
2:35
Treatment-resistant depression remains a significant challenge in psychiatric practice.
Daniel J. GuerraHOST
52:14
So even with that, all considerations, The dihomogamma linoleic acid could be a precursor to more arachidonate.
Daniel J. GuerraHOST
52:22
And in the literature since the 1980s, the reason we hear of omega-3 fatty acids in the diet, particularly EPA and DHA, is because it's been well known that the ratio of omega-6 to omega-3 is far too high in the diet.
Daniel J. GuerraHOST
52:39
Because human central nervous system lipid composition, therefore sequence of events, is typically deficient in the omega-3, not the omega-6.
Daniel J. GuerraHOST
52:55
And the dihomogamma linoleic acid is the omega-6.
Daniel J. GuerraHOST
56:20
The 24 carbon fatty acid will be desaturated and then will be essentially beta-oxidized back to the 22 carbon, and that will generate docosahexaenoid.
Daniel J. GuerraHOST
56:38
22, 6, 4, 7, 10, 13, 16, 19, where all those double bonds are, those six double bonds.
Daniel J. GuerraHOST
56:46
So you see, even the production of DHA from EPA is highly regulated.
Daniel J. GuerraHOST
56:53
And we don't have a delta-4 desaturase.
AloHOST
4:33
Researchers aren't fully sure why, but one idea is that these fats compete for space getting incorporated into your cell membranes.
AloHOST
4:41
This doesn't mean soybean oil is dangerous, but it does mean if you're eating a lot of plant-based polyunsaturated fat, You want to make sure you're also getting enough EPA and DHA from fatty fish or a decent fish oil or algae supplement.
AloHOST
4:56
That's just good practice regardless of which oils in your pantry.
AloHOST
5:00
Now let me be straight with you about the limits of this study because I always want to give you the full picture, not just the flattering parts.

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