Dose

And, like, we talk a lot.

And, like, one thing we were sharing a meme is, like, get your daily dose, D-O-S-E. dopamine, oxytocin, serotonin, and endorphins.

And it's like, it sounds so silly, but it's like, you'd be surprised at like, and I always joke with my friends.

I'm like, I'm like, I'm just trying to flood, have my brain just flood with all those good chemicals, like whatever it is for that day.

Have you ever seen Footloose?

I have seen Footloose, but it was almost like I micro-dosed Footloose or something.

It's blurry.

I really think you

And so then you've got this steadily declining concentration as you measure it serially over time.

And then eventually it will be eliminated completely from the body unless you give another dose.

So we're just talking about a one-off dose here.

And that gives you this triangular-shaped concentration time curve.

And we've got a little picture in the prep notes pointing out the different PD parameters that we've got.

And next, you've got C-max expressed as a function of MIC.

And this is what aminoglycosides do.

This is why you can dose them once daily, because you're going to get the maximal bacterial kill in a once daily dosing, but you will eliminate that toxicity phase from sustained exposure to aminoglycosides that happens in the kidneys.

Yes, exactly.

The editorial is called "Dose Matters" by Creutenberg and Mitra.

So we are going to deconstruct the conventional wisdom surrounding how we dose our neuromuscular blockade.

Which is so overdue.