Dopamine receptor D2
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Search complete. 11 mentions across 5 episodes found for "Dopamine receptor D2".
Nov 4, 2026
Mindy PelzHOST
And there was a really cool study, I will put it in the notes for you guys, that they found that food restriction increases dopamine receptors.
Mindy PelzHOST
And it's specifically what they call the D2 receptors.
Mindy PelzHOST
And they found that people who were obese actually had these less of these receptors.
Mindy PelzHOST
Well, that makes sense because when we've been using food as our dopamine source and constantly using food as our dopamine source, the same principles happening were flooding the receptor sites and they're shriveling up.
Mindy PelzHOST
So what this article shows, and I'll read you the final line of the study.
Mindy PelzHOST
This was a study done back in 2007.
Mindy PelzHOST
They found that when you restrict food intake, you can increase the number of D2 receptors.
Mindy PelzHOST
and that they also went on to say that those D2 receptors are slowing down as we age more, probably because we have more stimulus of dopamine.
Bryce WyldeHOST
We've heard this before where we're unique at the DNA company as we look at a few of these genes.
Bryce WyldeHOST
ADRA2B, we'll talk about this in detail, but this is the gene essentially in charge of adrenaline, COMT, or C-O-M-T, the speed at which we actually uncouple and metabolize dopamine and other catecholamines, the DRD2 gene responsible for dopamine, MAO, 5-HTTLPR, both of which are responsible for metabolizing and recirculating or recycling, if you will, serotonin and BDNF, brain-derived neurotrophic factor.
Bryce WyldeHOST
This is where I want to kind of focus our attention for a little bit and how we each express those differences and have variations within those genes really dictates at the end of the day how we manage stress.
Bryce WyldeHOST
Talk to us a little bit more in detail about the ADRA2B gene, because I know that's one of the first genes you look at in the executive profile that you can tell right away with your clients, ha, this is their predisposition to stress and how I'm going to maybe approach this individual as it pertains to stress in their life?
Bryce WyldeHOST
And if you go down the wrong pathway, that ultimately may have the physical or toxic stress burden to your body.
Bryce WyldeHOST
So once again, this is not just all psychological, emotional.
Bryce WyldeHOST
So DRD2 plays a role in that.
Bryce WyldeHOST
And tell us about the combination around the TPH2 gene, 5-HT-TLPR, all that stuff as it relates to serotonin that we often misconstrue as simply a happy hormone.
Jonathan BeauchampGUEST
And, uh, we, um, yeah, we were very interested into this.
Jonathan BeauchampGUEST
We saw a lot of claims of, you know, genes for entrepreneurship, genes for happiness, gene for risk-taking, gene for, like, the MAOA receptor, the DRD4, DRD2 dopamine receptor genes, and whatever trait you want.
Jonathan BeauchampGUEST
There was all these claims, so we're very skeptical of these, so we...
Jonathan BeauchampGUEST
Our first contribution was to show that lots of this was junk, basically.
Yael JaffeGUEST
So I mentioned the DRDs.
Yael JaffeGUEST
There's DRD2, 3, and 4, which are the dopamine receptor genes.
Yael JaffeGUEST
But there's also another very famous gene called COMT.
Yael JaffeGUEST
which is probably one of the best research genes in the literature.
Adilia SappGUEST
Sorry, I just had to interject 'cause it really aligns with my clinical experience as well.
Adilia SappGUEST
Just even when it comes to something like ADHD, we don't even know where it comes from, right? One of the most associated genes would be dopamine, and we could look at DRD2, we could look at other dopamine genes.
Adilia SappGUEST
We could look at COMT in terms of impulsivity and hyperactivity.
Adilia SappGUEST
But at the end of the day, it can come from a lot of different places.