Disulfiram
MedicationWikipedia
22
MENTIONS
14
EPISODES
14
PODCASTS
Search complete. 22 mentions across 14 episodes found for "Disulfiram".
Sep 21, 2026
Daniel Z. LiebermanGUEST
With alcohol, we have a drug called naltrexone, which reduces cravings.
Daniel Z. LiebermanGUEST
We also have a drug called Antabuse, my favorite, which makes people incredibly sick if they take even a sip of alcohol.
Daniel Z. LiebermanGUEST
And it sounds terrible, but people who take it say it's incredibly liberating because now there's no debate.
Daniel Z. LiebermanGUEST
They don't have to say, should I do this? Shouldn't I do it? Ah, if I do it, I will let myself down.
Chris DavisGUEST
Yeah, so acetaldehyde is toxic.
Chris DavisGUEST
And we've actually used that same pathway for one of the treatments, Antabuse, which is probably the one people have heard of, Disulfiram or Antabuse.
Chris DavisGUEST
That's a pill you take.
Chris DavisGUEST
It's a pill that you take every day that stops the body from breaking down acetaldehyde.
NatHOST
What is disulfiram? I've been on acamprosate.
NatHOST
That is the stuff that if you drink it, it makes you violently ill. Oh, that crap.
NatHOST
That's Antabuse.
NatHOST
Antabuse is the
MikeHOST
acamprosite plus naltrexone for me.
MikeHOST
I've said this in previous episodes, but for all of our new listeners, go back and listen to that.
speaker_0AUDIENCE
And I scheduled an appointment with my doctor, and he immediately did an audit test, and I came back as high-risk.
speaker_0AUDIENCE
Rather than even discussing GLP-1s with me, he prescribed Antabuse and Cholesterol, alcohol counseling because he said that they don't prescribe GLP-1s through our insurance.
speaker_0AUDIENCE
But at the same time, it just like sent me into panic when that was the option that he offered.
speaker_0AUDIENCE
The idea of just cutting alcohol out completely and still having the voice in the back of my head was terrifying.
John DelonyHOST
Because you're going to take the batteries out of the alarm, but your house is going to burn down around you.
John DelonyHOST
And so I'm 100% with your doctor here.
John DelonyHOST
I don't know the, like, Antabuse has a whole bunch of, by the way, for those of you who don't know, Antabuse is, it's a medication you take that when you drink alcohol, you become violently ill.
John DelonyHOST
It makes you, it makes the drink so awful for your body that you stay away.
PaulAUDIENCE
I, you know, got some medicine to try to help with drinking and, you know, some Ativan, which is like Valium to relax a little.
Walter SterlingHOST
Did they give you Antabuse? Did you take Antabuse?
PaulAUDIENCE
No, no.
PaulAUDIENCE
They wanted to give me
Dave MacGUEST
And he wanted to put me on some medications to stop me drinking.
Dave MacGUEST
And I can't remember the name of the medication now, but basically it's one where you take it, nothing happens, but if you drink, then you get violently ill. Antabuse.
Dave MacGUEST
Antabuse, that's it.
Dave MacGUEST
And I think one of the side effects of that was quite scary for me because the side effect is basically death.
Jamie DelaneyHOST
Yes.
Ram SundarichGUEST
Insomnia, where that's a huge trigger, gabapentin is something to think about.
Ram SundarichGUEST
Disulfiram is the very carefully selected patient who is specifically interested in that motivator of taking alcohol off the table.
Ram SundarichGUEST
The GLP-1s are super promising.
Ram SundarichGUEST
The coverage from an insurance standpoint is really gonna be for those folks who have obesity, they have diabetes.
Richard HorowitzGUEST
There's only two that are available.
Richard HorowitzGUEST
Dapsone combination therapy and disulfiram.
Richard HorowitzGUEST
Antabuse, the drug we learned in medical school to use for alcoholics.
Dean MitchellHOST
Oh, wow.
Richard HorowitzGUEST
So that was discovered by Stanford University.
Jessica SpissingerHOST
When you drink alcohol.
Mercedes DodgeHOST
Yeah, so it's known as the Antabuse.
Mercedes DodgeHOST
And so I have a couple of patients that have come to me and say, "I'll never take anything again for alcohol use," and it's-- I was like, "Oh, you had Antabuse, didn't you?" And they're like, "Yeah." [laughs] I was like, "Oh." And but then there's actually a couple patients I have had that said, "Give me the Antabuse or disulfiram." And I'm like, "Are you sure?" They're like, "Yeah, that's what motivates me." And their mindset is, "Okay, if that's what you need, and if that's what you are aligned with, and you know the consequences, then that's perfect for you." And the reason why I really like naltrexone and where I think that we all need to continue getting comfortable, 'cause obviously we're-- just to back up just a little bit.
Mercedes DodgeHOST
So when we're talking about medications, a patient comes in, we have to do all the other steps, right? That truth encounter, finding their ambivalence, the motivational interviewing.
Mercedes DodgeHOST
Because just saying, "Oh, you have this," from the S of the SBIRT-
Scott T.GUEST
My Army career, before that was over, I had four Article 15s.
Scott T.GUEST
I was on the Benning House program of alcoholism, taking Antabuse every morning in front of the CO.
Scott T.GUEST
Anybody ever have Antabuse? Anybody ever try to drink on Antabuse? [laughs] Our cases are different.
Scott T.GUEST
Yeah, all right.
speaker_4UNKNOWN
[laughs]
4 more episodes mention Disulfiram.
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