Dihydropyrimidine dehydrogenase (NADP+)
Chemical compoundWikipedia
15
MENTIONS
2
EPISODES
2
PODCASTS
Search complete. 15 mentions across 2 episodes found for "Dihydropyrimidine dehydrogenase (NADP+)".
Sep 30, 2026
Samira DaswaniHOST
What questions would you want them to ask their treating oncologists in order to get tested?
Gabriel BrooksGUEST
The simple thing to ask is, you know, what drugs are you recommending for me? The specific question is if the treatment is going to include either 5-FU, which is an abbreviation for 5-fluoruracil, or if it's going to include capecitabine, do I need to be tested for DPD deficiency or do I need to have a DPYD gene test? The answer should be yes.
Samira DaswaniHOST
I have a very cool guest who has been on this podcast before, but many, many years ago.
Samira DaswaniHOST
And it's one of those episodes that I distinctly remember because I walked away having actually understood the incentives around our healthcare system.
Gabriel BrooksGUEST
I'm glad to be back.
Samira DaswaniHOST
Dr. Brooks, today we're talking about, I think something that has, at least to my knowledge, not been discussed very much, but is sort of foundational to where this ecosystem should be going.
Samira DaswaniHOST
We're talking about DPYD.
Samira DaswaniHOST
Can you maybe just start by telling us what the heck is it and why do we care?
LynnGUEST
Our teams are working very closely together and it's proven to be a strong addition into the Novosight portfolio of products and services.
LynnGUEST
In addition to non-organic growth throughout Southern Cross, we also launched our Your Gene Insight DPYD assay.
LynnGUEST
So we continue to deliver on the commitment to bring new product to our customer base and to the global market.
LynnGUEST
This particular assay is for patients that are using 5-FU chemotherapy.
LynnGUEST
Some of those patients lack a gene, the DPYD gene, which means the chemotherapy attacks the patient, their organs, as well as the cancer.
LynnGUEST
So this is a life saving product.
LynnGUEST
We estimate probably one in 100 patients who have this product lives will be saved by either not giving the chemotherapy dose or reducing that dose.
LynnGUEST
And I'm delighted to say our product is the most complete product in the market.