Diffuse intrinsic pontine glioma
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Search complete. 78 mentions across 15 episodes found for "Diffuse intrinsic pontine glioma".
Nov 3, 2026
Kurt DeGrootGUEST
Yeah, we actually have this cool story that just happened in the last couple weeks.
Kurt DeGrootGUEST
We unfortunately have a child in Arizona that is diagnosed with DIPG.
Kurt DeGrootGUEST
Again, the bad brain cancer.
Kurt DeGrootGUEST
Yeah.
Eric NewmanGUEST
So yeah.
Eric NewmanGUEST
But was there ever moments this Saturday I was on my kids watching my kid play baseball and I got a text message about a little boy diagnosed with DIPG.
Eric NewmanGUEST
He's got a couple of weeks to live.
Eric NewmanGUEST
So in this, I'm like, I can't take this anymore.
Becker HallGUEST
And so Donald link through Renee's relationships, donated our first hog to us.
Becker HallGUEST
And about a month before we decided to do it through his kind of You know, through the food news, he heard of a chef, a sous chef that we had gone to high school with and grew up in our area, whose son had an inoperable tumor called DIPG.
speaker_5UNKNOWN
And
Becker HallGUEST
it is one of the most fatal tumors there is.
JanieGUEST
And that was the moment, that was the before.
JanieGUEST
And we, Brent and I, my husband, we quickly found out that the type of brain tumor Nora had, the acronym is DIPG.
JanieGUEST
That stands for diffuse intrinsic pontine glioma.
JanieGUEST
So it's a pretty big word.
JanieGUEST
We are blessed enough to have a strong community that we've been able to turn our pain into purpose.
JanieGUEST
And now the organization is called Nora's Sparkle of Love Project, and we support other pediatric brain cancer families and other pediatric cancers, not just brain cancer.
JanieGUEST
We contribute to research for DIPG and support.
JanieGUEST
We are super excited that we started an endowment with St. Louis Children's to support their facility dog program and grow it.
Heather GrahamGUEST
And unfortunately, she did not survive.
Heather GrahamGUEST
She had DIPG.
Heather GrahamGUEST
And that's where you hear these things, oh, childhood cancer is rare.
Heather GrahamGUEST
It's not that rare.
Laura FredricksonGUEST
I can't even remember.
Laura FredricksonGUEST
It was like four or five different people that were there to give us the news that Francisco indeed had DIPG.
Laura FredricksonGUEST
And his prognosis was of six to nine months, 12 months if we were lucky.
Laura FredricksonGUEST
And yeah, that was diagnosis day.
19 MINS LATER
Laura FredricksonGUEST
So most of his... motor skills were going or gone.
Laura FredricksonGUEST
And I completely forgot to mention that this is what his cancer does.
Laura FredricksonGUEST
DIPG is a cancer that's located in the brainstem.
Laura FredricksonGUEST
So it's kind of like, you know, central command for the entire body.
Parker MossHOST
That's absolutely thrilling.
Parker MossHOST
I'll be following the interest and of course this approach which can be given to patients with non-resectable tumors I presume will be very well suited to those horrendous pediatric cancers like DIPG and DMG which are famously unresectable.
Parker MossHOST
So I I hope there'll be a pediatric angle one day as well.
Parker MossHOST
Let's just step way back from the science for a minute and just talk us through your experience of really going from a basic scientist, a developmental fetal biologist, a stem cell biologist, to now being a CSO at a venture-backed company.
Jiasen HeHOST
While newer approaches including Dodavipro have generated excitement, the clinical benefit remains limited.
Jiasen HeHOST
One of the fascinating findings from your study is the observation that RAS pathway is upregulated in DMG and this tumor appears to be highly dependent on the RAS signaling.
Jiasen HeHOST
Could you first explain for our listeners what RAS is and why it is such an important pathway in cancer biology? And perhaps more importantly, why has RAS historically been considered so difficult to target, particularly in the context of diffuse midline reamer?
Stefanie-Grace SbergioGUEST
Yes, I could take the lead on this.
Stefanie-Grace SbergioGUEST
to lead to the sustained activation of this pathway.
Stefanie-Grace SbergioGUEST
And so in cancers where there's upregulation of a cell surface protein or a mutation in RAS, you may suspect that we could target RAS directly or we could target somewhere in the pathway to perturb this and kill the tumor cells.
Stefanie-Grace SbergioGUEST
And so for DMG, in the last few years, there's been several publications that start to introduce RAS as a potential vulnerability.
Stefanie-Grace SbergioGUEST
And so we specifically look closely at this and see that based on RNA-seq and proteomics, there is a significant upregulation of the RasMAP-Kydase signaling pathway.
Laura FredricksonGUEST
So, um, First of all, the cancer that he had is not a common one.
Laura FredricksonGUEST
It's called DIPG.
Laura FredricksonGUEST
It's terminal brain cancer.
Laura FredricksonGUEST
And they call it pediatric brain cancer, even though there are some adults that get it, but the ages are mostly between seven and nine years old.
18 MINS LATER
Laura FredricksonGUEST
Yeah.
Laura FredricksonGUEST
So he was, it was unusual.
Laura FredricksonGUEST
We do have in the DIPG community, you know, the outliers, you know, little cases where a child will live maybe for like four or five years, but most, most children I think now with the treatments and with different trials that seem to help a little bit, that has been prolonged a bit.
Laura FredricksonGUEST
I think now 12 months is more, you know, the average.
Lloyd JacksonHOST
Pur- mm-hmm.
Jamie EdmondsHOST
And raise a lot of money for DIPG in honor of their little brother.
Jamie EdmondsHOST
So good stuff from the Carr family.
Jamie EdmondsHOST
Coming up on JR Morning, the 8:00 hour, it's Pistons opening day tomorrow.
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