Diamine oxidase

broths? They have to pop an antihistamine before they take the bone broth,

right? Or a DAO supplement.

A DAO supplement.

Okay, so if they were to take a DAO supplement and then have the bone broth, that would be good.

So I generally don't recommend fermented, preserved foods in histamine issues anyway.

So I don't – I have this little caveat.

That's probably what your body wants.

It just doesn't really want the histamine side of it.

Certain supplements can be really beneficial.

So she started on things like DAO and quercetin, which help break down histamine in the body.

And even things like extreme temperatures can actually be histamine producing in the body.

So she was doing the sauna.

This is where your mast cells in your body are releasing histamine constantly.

They are not working as they should.

And like I mentioned earlier, if you have variants in your body that make it harder for you to break down histamine, variants include things like DAO and HNMT that we test for.

If you're not breaking down the histamine, then you can have symptoms like brain fog, puffy eyes, headaches, GI issues, basically anxiety because of the nervous system dysregulation.

Like I said, alcohol is really depleting.

So some of those supplement packets that you're supposed to take right when you start drinking, even histamine, you know, people will take the enzyme that breaks down histamine called DAO.

They'll do that before they drink.

Definitely can help manage the situation.

what I mentioned earlier, when we eat foods high in histamine or foods that create histamine in the GI tract, that can add to the bucket.

So now I'm like, well, as we age, our ability to break down that histamine out of the GI tract declines.

So maybe we need to add in not just digestive enzymes, but we need to add in specifically that DAO enzyme.

Yeah.

This contributes to the proliferation or growth of endo lesions.

And then when we have higher levels of estrogen, this down regulates an enzyme called DAO or diamine oxidase.

This is an enzyme that's really helpful in breaking down histamine in the gut.

So again, it's all connected.

So we really want to think about how can we support histamine clearance.

The two main pathways are the two main enzymes that I think about.

One is DAO, that enzyme that degrades histamine in the gut.

It is produced by enterocytes or the cells in your small intestine.

But there are certain organs that have enzymes to help you dismantle and break down histamines.

And the first one is called diamine oxidase.

We're just going to call it DAO.

So this enzyme is located in the small intestine as well as your kidney.

Now it's in the small intestine because of all the histamines you get from foods.

You know, there are herbs that help too.

Things like vitamin C and stinging nettles and DAO enzyme is my absolute favorite if people need it.

Bifidobacterium probiotic.

But sometimes if people are really far off and their neuroimmune system is so swung out, it can't calm down, you need pharmaceuticals.

So not everyone needs a probiotic right away.

And a lot of times if I do it, it's the end of the heal and seal program, especially if I've got an MCAS patient or someone struggling with histamine and they've had a lot of antibiotics in the past or a lot of leaky gut symptoms.

I will use sometimes something like a spore-based probiotic, a bifidobacterium at the end, which helps make DAO that breaks down histamine.

And that's really helpful for a lot of these people.

I want you to look into, talk to your doctor, right? I'm not a doctor.

DAO supplement.

You heard of this? It's my favorite supplement.

I feel like it's

floated around.

Yeah.

DAO.

I don't sell supplements, by the way.

There's no test.

So possible contributors include reduced DAO, which is an enzyme that breaks down histamine.

It can be certain medications.

It can be gastrointestinal problems.

Either way, you just want to avoid them.

And there are enzyme inhibitors.

Remember we talked about DAO, which is diamine oxidase, that breaks down histamine.

Well, there's actually foods that inhibit the production of this enzyme, so that's a double whammy.