Deoxyribonuclease

And the reason why it's a problem, say, yeah, but it still has active ingredients in there.

Well, guess what? It also has DNases, and these are enzymes that when cells die, they release, it causes cells to aggregate.

Not only that, it causes other cells to die.

Mm-hmm.

People don't understand that.

People think, "Well, so what? I have what's inside of a cell, and it has good stuff in it in the stem cell, so it doesn't matter." That's not true, because when cells die, they release DNases, and these are enzymes that can be detrimental and can actually cause killing of other cells.

So in that gemisch that you thawed out, if you have a bunch of dead stuff in there, you've now had stuff that can cause self-perpetuating death to other cells.

So there's a lot of moving parts here.

Yeah.

Why does the treatment suddenly have to escalate to VATS or intrapleural tPA and DNase?

Because the inflammatory cascade alters the fluid.

In that second week, the immune system starts throwing down thick fibrin strands, creating loculations or complex pockets of pus that a simple chest tube cannot drain.

Ah, it gets trapped.

Exactly.

The tPA and DNase are enzymes used to literally digest and break up that thick fibrinous sludge so it can flow out.

And if they progress to week three, the organized phase, it’s a nightmare.

But if I have my phone against the ear, within minutes, you're starting to break down the blood brain barrier.

What people don't realize is it's been studied and shown that the DNAase, that's important, DNAase is then released.

What is DNAase? It's the enzyme that breaks down your DNA.

Does that sound good? No, it's not.

And so like when we're on our phone planning a birthday party or a baby shower or our wedding or talking gossip, don't do that, that's bad.