Denosumab
DrugWikipedia
27
MENTIONS
18
EPISODES
17
PODCASTS
Search complete. 27 mentions across 18 episodes found for "Denosumab".
Nov 4, 2026
Jimmy StewartHOST
But in reality, it's really low.
Jimmy StewartHOST
Now, the Bain holdup for the other classes that we have, there's things called Prolia, which is a biologic.
Jimmy StewartHOST
So it's a monoclonal antibody and it acts differently and doesn't have some of the side effects.
Jimmy StewartHOST
And the other good thing is you can just get it like an injection, usually like, you know, much less, like once a year.
Anika Kim-ConstantinoCORRESPONDENT
That includes Repatha, a drug that lowers bad cholesterol, which jumped 37% to 1.09 billion in sales, and osteoporosis drug Avidity, which jumped 39% to $751 million in sales.
Anika Kim-ConstantinoCORRESPONDENT
To no surprise, we saw weakness with another osteoporosis drug, Prolia, with sales coming in below estimates due to biosimilar competition here.
Melissa LeeHOST
Yeah, the stock is not doing too much here, Annika.
Melissa LeeHOST
It looks like their forecast for full year adjusted earnings came in a little bit below 22 to 23, and analysts were at 23.02.
Carmen StansberryGUEST
I was telling you with our own parents that they were afraid of hormone therapy.
Carmen StansberryGUEST
A lot of these women in their 70s and 80s have pretty significant osteoporosis because they didn't do hormone therapy or they're doing medications like Prolia.
Carmen StansberryGUEST
that are helping them build bone because it wasn't maintained through perimenopause.
Carmen StansberryGUEST
Or maybe they're being treated with blood pressure medication that they wouldn't normally have needed if they were on hormone therapy, for example.
Leona MadisonGUEST
And so I was put on the Prevalo.
Leona MadisonGUEST
Prolia.
Kimberly MadisonHOST
Prolia.
Kimberly MadisonHOST
Stayed on for three
Leona MadisonGUEST
years.
Heather HirschHOST
Now, is it helpful if you have osteoporosis? I would say that's where I might say you might need something more.
Heather HirschHOST
In the bone agent classification, that could be Prolia, that could be Reclass, that could even be Fosamax.
Heather HirschHOST
But if you have osteopenia or you want to protect your bones, Menastar is a really good choice.
Heather HirschHOST
Now, what I also love about the Menastar patch, and this is a nuanced conversation, is women will say, like Jodi, I don't have significant symptoms anymore.
Eric ChristensenHOST
Alright, let's get into the medications we're going to cover today.
Eric ChristensenHOST
The first medication I want to mention is Denosumab.
Eric ChristensenHOST
Brand name is Prolia.
Eric ChristensenHOST
This is a monoclonal antibody that inhibits rank ligand, often abbreviated as rank L.
Debi RobinsonHOST
And I honestly don't think most of the physicians are as educated as you are on all of these different pathways and the interactions with all the drugs.
Debi RobinsonHOST
And so whatever the drug du jour, right now it's Prolia, which with Prolia, then you have to go on the anti-reabsorptive.
Debi RobinsonHOST
Usually it's reclassed.
Debi RobinsonHOST
women don't want that they're really not given another option and the endocrinologist or family practitioner gynecologist that's managing their bone health with that recommendation of a drug is not the person that's also looking at their heart maybe has them on a statin or maybe has them on something else so it's really really hard for women out there especially women who are naturally minded who want a little bit more information for themselves like okay So I have osteoporosis and I have menopause.
Debi RobinsonHOST
Yeah, that it's good for maybe it's good for breast tissue.
Debi RobinsonHOST
It's good for bone tissue.
Debi RobinsonHOST
So even the fact that Evista doesn't seem to be the drug that's recommended right now, the real drug du jour is Prolia.
Debi RobinsonHOST
Well,
Brian RedmondHOST
Hopefully, you won't need my guidance, that's for sure.
Brian RedmondHOST
Could you ask about Prolia injection? P-R-O-L-I-A is how that's spelled.
Brian RedmondHOST
Does that make sense to you, Sol Sinead?
Sinead ByrneGUEST
Yes.
Sinead ByrneGUEST
Yes, Prolia is an injection for osteoporosis.
Sinead ByrneGUEST
It's a really effective drug.
Sinead ByrneGUEST
And you get it once every six months.
Sinead ByrneGUEST
Exactly.
Belinda BeckGUEST
Some people do have nasty sort of flu-like reactions to them, but most people can tolerate them.
Belinda BeckGUEST
And they're probably the safest anti-resorptive drug in terms of not having this big rebound effect that denosumab or Prolia has.
Belinda BeckGUEST
Now, the anabolic drugs, these tend to be given as an injection, a daily injection, just like if you had diabetes and you're giving yourself an insulin injection, it's the same sort of thing.
Belinda BeckGUEST
Because you can't take them by mouth because your body will break them down in your stomach.
Doug LucasHOST
in a New England Journal trial.
Doug LucasHOST
What about Denosumab? That's Prolia.
Doug LucasHOST
It crossed a 5% total hip change only around year three.
Doug LucasHOST
And we're talking about 7% at the hip in one year.
8 more episodes mention Denosumab.
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