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David Simpson

David Simpson

Sep 16, 2026

16:37
In fact, in 2009, the FDA put a black box warning on this drug and others like it, a reminder that they can cause serious complications, including difficulty breathing.
16:48
Now, that's extremely rare in the doses we use, but the more common concern is that in the process of causing localized muscle weakness, which is what we're trying to do, it can cause excess weakness of the muscle you're injecting, or it can spread to other muscles.
17:08
For example, if you're injecting a patient with facial spasm around the eye, and the botulinum toxin spreads to the muscle that keeps the eyelid open, you can get a droopy lid.
17:21
And so there's really a skill set that needs to be learned.
17:27
In fact, I usually encourage doctors to find a mentor to train them properly, almost like surgery.
17:35
I often say there's a lot of science in the field, but there's also a lot of art that needs to be passed through the generations.
17:52
It all feels sort of much more, I don't know, kind of ad hoc and creative than I think we're used to thinking of it.
17:59
Well...
AlexHOST
62:00
what point do you think ah yeah great i'm going to make my own from scratch
62:03
So the point was actually the resistance we were getting from the machine manufacturer at the time, I built up a good reputation with them.
62:15
I kept on going back to them and said, this isn't right.
62:17
This isn't right.
62:18
I've changed this and it's made this better.
62:20
I've changed that.
62:22
Yeah, okay.

7 MINS LATER

LeoHOST
69:14
And so how are you managing all of that? Is that why Cy's come
7:11
What does a typical day look like for you at United, you know, from pre-flight to landing?
7:17
That question...
7:20
Depends on if I'm doing a domestic flight or an international flight.
7:25
If I'm doing a domestic flight, the two pilots tend to show up at the aircraft and we're often meeting right then.
7:34
We don't usually know each other, often never seen each other before.
7:40
With over 18,000, 19,000 pilots here at United Airlines, it's hard for us to all know each other.
7:47
But you meet at the aircraft and we'll go through the paperwork together.

10 MINS LATER

17:43
What advice do you have for any young people listening that have a similar dream of getting into aviation? So what advice do you have for them? A
MikeHOST
1:05
we've been out there monitoring the performance of the stormwater
1:08
system.
1:09
As you know, a lot of high flows over the weekend that are really stressing the operating capacity of our sewers, our pumping stations.
1:17
So Our crew's been out there regularly cleaning stormwater catch basins.
1:22
We're doing our best to keep all of the large municipal drains free of debris.
1:27
And we keep monitoring and optimizing the rate at which our pumping stations are performing, too, just to keep pace.
MikeHOST
2:31
Clearing those out, will that help in a situation like this, or is it simply too much rain in too little time?
2:38
No, you're bang on, Mike.
21:37
In fact, in 2009, the FDA put a black box warning on this drug and others like it, a reminder that they can cause serious complications, including difficulty breathing.
21:48
Now, that's extremely rare in the doses we use, but the more common concern is that in the process of causing localized muscle weakness, which is what we're trying to do, it can cause excess weakness of the muscle you're injecting.
22:05
Hmm.
22:06
Or it can spread to other muscles.
22:08
For example, if you're injecting a patient with facial spasm around the eye, and the botulinum toxin spreads to the muscle that keeps the eyelid open, you can get a droopy lid.
22:21
And so there's really a, a skill set that needs to be learned.
22:27
In fact, I usually encourage doctors to find a mentor to train them properly, almost like surgery.
22:36
I often say there's a lot of science in the field, but there's also a lot of art-

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