Damage-associated molecular pattern

It's an array of events that almost like dominoes, one topples the other and it just continues on down.

And the reality is when you're talking about things like damage-associated molecular patterns, we call those DAMPs.

There's also pathogen-associated molecular patterns that we call PAMPs.

The best thing to understand from a layperson standpoint is that It's just creating a debris field.

So when our own tissue is damaged or there's pieces of organisms that get into circulation...

Those, we call them PAMPs or MAMPs, microbial associated molecular peptides and DAMPs, damage associated molecular peptides, which is our own tissue.

They get into circulation, they bind to receptors on immune cells and that activates the immune system and says, hey, here's the piece of tissue that's been damaged.

Go there and help, right? Activate the forces and go help.

Now we know what we're looking for is the problem, essentially.

And that's how we activate the immune system.

But those same DAMPs, PAMPs, MAMPs are in circulation, but the thyroid cell itself has receptors for those.

And when those particles bind to the thyroid cell's toll-like receptors, that initiates, it can convert the thyroid cell into an immune-like cell that it initiates its own immune inflammatory process.

When it comes to inflammation, this is a key driver of neurodegenerative conditions.

So when a neuron is damaged, it releases what we call DAMPs, which are danger signals, and that instigates a bit of a response.

It perpetuates inflammation, and we see s- cell loss.

So we consider that.