Cytarabine

Remember the BRITE trial that we mentioned in the follicular episode that looked at BR? Well, the BRITE trial also contained mantle patients, and BR is generally the go-to chemo option in Australia for these patients.

People were really curious from the upfront younger patient therapy about how beneficial Cytarabine was.

So there is this hybrid regimen you can use called RBAC that adds a bit of Cytarabine to BR for your, I guess, more fit, unfit patients, I suppose.

Yeah.

There is also evidence for adding a Bruton's tyrosine kinase or BTK inhibitor to BR, for instance, acalabrutinib BR in the ECHO trial that shows prolonged PFS, although the overall survival data is still maturing.