CYP1A2

And that's the one that changed my life the most.

So phase one and phase two liver detox, the CYP450 enzymes, CYP1A1, 1A2, 2E1, CYP3A4 and the rest.

The GST family that I mentioned, GSTM1 and the P1 and then there's NAT2 and PON1 and the vitamin D pathway genes.

CYP2R1 and the VDR receptors, lots of gobbledygook.

Yeah.

So it doesn't, I mean, it does have, it's a CYP1A2 inhibitor.

I'm like double checking.

Yes.

So first of all, there are various genes that are somehow related to it.

When it comes to pure caffeine metabolism, so the breakdown of caffeine, we have a gene that codes for that, and that's CYP1A2.

And that, yeah, there are different versions of it.

You can either be AA, I won't go deeper into that, or you can be CC or AC.

And then you have the slow metabolizers who are at about 10 to 15%.

So not actually that many, but of course, those are people who have to be extremely careful because they really shouldn't drink coffee after, I don't know, 11, 12 o'clock under any circumstances because they'll simply really still notice a difference in their sleep architecture.

But now it's not just CYP1A2.

I, in this case, am actually a fast metabolizer, which I never would have thought because I'm actually very sensitive to caffeine.

Interesting.

So knowing like what your liver enzyme, um, genetic markers are is can be helpful like at the high level for sure um if you've ever done 23andme you can look it up um oftentimes like if you you can look up your snip they call it a single nucleotide polymorphism like code for the CYP1A2 gene for our listeners oh okay cool but huh yeah yeah yeah

I do I take caffeine for the the XCO um and that I mean like yeah that

works for me for sure.

Yeah.

Caffeine is extensively metabolized in the liver, primarily by an enzyme called CYP1A2.

Okay, CYP1A2.

Right.

And as this enzyme breaks down the caffeine, it creates three entirely new active metabolites.

It clears it out at a steady percentage rate, usually a half-life of about three to five hours.

Right.

But if you flood the system with high doses, the CYP1A2 enzymes in your liver become completely saturated.

And so some of us, myself included, are rapid metabolizers.

He's talking about the CYP1A2 gene, a landmark study in JAMA found that people with slow variants of this gene who consumed two to three cups of coffee daily had a 36% increased risk of heart attack, while fast metabolizers had a decreased risk.

Whereas a slow metabolizer, and again, it's about 50-50.

So you have half of the population who's slow metabolizers, which means they're going to accumulate caffeine during the day, which means it's going to have an adverse effect on them.

I know it's going to affect my sleep.

But I think you mentioned a very interesting point that people have different abilities to handle The breakdown of caffeine, there's what's called the CYP1A2 gene, and variations of that gene can determine whether you can or cannot metabolize that caffeine appropriately.

As such... caffeine may affect you more than the next person.

So it's good to know that.