Continuous positive airway pressure

It was great.

And Mike puts on Bud's CPAP machine.

We're having some laughs.

That was fun.

But even pressure support, I don't necessarily fully agree that it is truly spontaneous because you can still have dyssynchronies.

So how can it be actually fully spontaneous? You know what I mean? So I guess in my mind, though, I might not agree with any of the big brains, but I truly think full spontaneous, you know, breathing essentially would have someone on, you know, CPAP on, you know, looking at their respiratory pattern.

Yes, you can match so that they are fully driving.

But like, is it really spontaneous? Depends if you've matched well and they are not having any cycling issues, even in fresh sport.

So the

Esteban paper, 95.

So SIMV longer, rate of reintubation the same with PS of, I forget, 8 over 5, and then maybe CPAP of something, and then SIMV of whatever.

But, you know, longer length, this mechanical ventilation on SIMV, because you're sitting there waiting for people to sort of like, wean from the vent, which is, you know, not like you sort of like don't need to wean because there's nothing to wean.

Welcome back to Global Trials Accelerators, the podcast where we dismantle the barriers to clinical innovation and explore the strategies driving the next generation of life-saving therapies.

Millions of people worldwide suffer from obstructive sleep apnea, yet nearly half of all patients abandon traditional continuous positive airway pressure, or CPAP, therapy because of the sheer physical discomfort.

The engineering to solve this problem often originates inside world-class university laboratories, but taking a disruptive medical device out of the academic institution and into the commercial market is one of the most complex journeys in medtech.

Our guest today is driving that exact transition.

Yeah, so like you said, beyond the obvious financial assistance, I genuinely believe it's life or death.

Without the NIH's support, this technology would have never made it this far.

And now, since we're trying to go to the next step and develop a new prototype that is smaller, can be used by a clinician in the sleep clinic more easily, and has all the features that our traditional CPAP machine would have, but with our technology for the airflow.

Without the support that NIH gave us, this technology would have just

Will you entertain a sleep question? Yes.

When you got your CPAP machine, you had your sleep study, then you had a follow-up.

Right.

How many follow-ups before you actually got your machine and your mask?

I knew a guy that knew a guy.

How do you know a

CPAP guy? That's not a guy people usually know.

His

and then we gradually reduce the help from the ventilator and historically when the ventilator is all but back in the cupboard we then think about taking the cuff down and taking the tube out.

So these sort of processes have usually happened in a sort of linear time and when the support comes down patient gets onto CPAP or a trachea mask and then towards the end of that process we go oh maybe we should take the cuff down.

Obviously when the cuff is down we restore airflow through the upper airway We start thinking about the patient's voice.

We start thinking about speaking vowels.

And that was part of my whole mess at the beginning.

And I have responded very well to the CPAP machine.

And in fact, it's sort of like my blankie at this point.

I know I need it and want it to have a good night's sleep.

I go to bed at nine 31 and, And I wake up around 5, 5.30 in the morning without an alarm clock with, you know, would I like a little bit more deep sleep? Sure.

But like getting the sleep study, first I did it at home, then I did it in lab study.

And then we did the CPAP.

And then with our physicians at Rebel, you know, we dialed in.

So they got her out within, you know, the four minutes.

And she needed a little bit of CPAP.

She needed some PPP,

which is just like a little bit of like

oxygen to help her breathe.

Her first out-car was two, but she was fine.

Needed CPAP for a few hours after birth, but then she was fine.

Me, on the other hand, I was circling the drain, as us nurses would say.

He's at this point wearing a BiPAP mask, which is like a full face where they force air into.

I don't know if you're familiar with the CPAP, but it's basically a full face CPAP.

Sure.

So instead of just the nose, it covers the nose and the mouth.