Common fruit fly

Love you guys.

Well, I think it definitely applies to just the fruit fly because they-

It is

...

Number 16.

I'm losing the battle against fruit flies in my house right now.

Why does this one feel like such a confession? Because one, I had somebody come over the other day and she did not mean ill at all, like whatsoever.

But she said, oh my gosh, look, there's so many fruit flies in here.

And it embarrassed me.

Transparently, I was just like, I no, I can't keep up with like, oh, I'm like such a mess.

Whatever.

The point of this is after doing some soul searching, after laughing it off, I realized that it's much deeper.

Okay.

So what is Notch? Notch is a gene that was discovered in Drosophila.

So when you do mutations in Drosophila and get a phenotype, you often would name the gene based on what the mutant phenotype looks like.

So for those of you looking online, Drosophila, of course, is a fruit fly and is a fantastic genetic model organism, a multicellular model organism.

Wonderful.

Takeko, actually, in our lab, my wife, is... a Drosophila developmental geneticist.

In fact, she discovered a gene called MEO, missing oocyte, because if you have a mutation in the MEO gene, the female flies don't make any oocytes.

So notch, if you're looking here, a typical wing on a fly is nice and smooth.

And the horsefly was pretending to be a business lady.

And then the other character was Drosophila melanogaster, the fruit fly, who was pretending to be a lab technician.

And this was Ottavia.

And so I was working with these characters, but somehow over the process, it was not so important anymore what beings they are if they are flies or if they are humans it was more like what connected them that they were like longing for something and it was like a desire they were like um hunting somehow so also they go through different relationships between each other um between being as flies between being as humans um between the audience

Yeah, I had, like, different online libraries where I collected all kind of facts.

And then there was also this, like, one...

Because Drosophila melanogaster, the fruit fly, is, like, the most studied fly.

And there were also some, like... effects like she's using just one wing and then she's vibrating one wing this is like a sign that she flirts and this kind of small details we also used in like how we approach movement that otavia had had this like floating gesture

you look at a variety of experimental models and you see them happening and you see them having effect on the physiology of the organism as it ages, right? So you can see these in yeast, you can see these invertebrates like, or sorry, in invertebrates like C.

elegans and Drosophila, the fly, or, you know, pushing into vertebrates and into mammals, you see these hallmarks showing, you know, similarities, right? So yeah, I think we're still in the very early stages of understanding ours and understanding how it fits into the bigger scheme.

But I think we've been able to use our model and C. elegans to its strengths to hopefully uncover something that's meaningful to cell biology and aging.

As someone who worked on worms a lot, I definitely agree with you.

Quote of the day here in a second.

So California battling some of the most aggressive fruit flies ever.

And why? How do you get them out? They're nagging.

I don't think they can really hurt you, but-

But just like-

Because of the flies?

Yes, and that'll also help with fruit flies.

I've never done that in my life.

But yeah, listeners, please write in, email at retrogameclub.net. That is email at retrogameclub.net.

If you played Metroid, Grand Theft Auto, Chinatown Wars, Metal Storm, any Picross game, or if you are controlled by Fruit Flies.

We have some great feedback this episode.

Dean writes in about, I think, yeah, I talked about how I almost picked Devil May Cry.

Yeah, that is your preschool song for the day.

But anyway, I have heard of people taking the Fruitfly Connectome and using it as an operating system for doing more than just playing video games.

Some people are using them to send emails or to filter their emails.

Some people are using the Fruitfly.

Can you imagine if we hit that, though? This would be the most exciting podcast on the internet.

I want to give, I want to fruit fly for the pod that will like, we reward it for complimenting, complimenting our...

Basically send a message to Blockstream being like, I'm a good guy.

Let me know how I can give this Bitcoin back to you.

Okay.

You didn't want to explain Navi or Stokes and the fluid dynamics, but please tell me.

What is in the mind of a fruit fly and why is that important to us?

Okay, so some researchers, I think from Google, open sourced fruit fly connectome, which is like a model of a fruit fly's brain.