Coenzyme A
Chemical compoundWikipedia
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Search complete. 86 mentions across 8 episodes found for "Coenzyme A".
Nov 12, 2026
Peter OsborneHOST
So a lot of people are predisposed or at risk for infection when their B5 levels are low.
Peter OsborneHOST
Now we get B5, this diagram here, and you see you can eat B5, PAN, that's pantothenate or pantothenic acid, and then CoA, CoA can also be eaten.
Peter OsborneHOST
And remember, pantothenic acid produces CoA.
Peter OsborneHOST
but you can also eat it.
Peter OsborneHOST
So what happens is when you eat the panathenic acid, it's absorbed and then as it goes.
Peter OsborneHOST
If you're taking high doses of vitamin B5, you might be contributing to reduced biotin uptake because they both go through this same transporter.
Peter OsborneHOST
So you're going to have, if you're overdosing on one for a very long time without getting it measured or tested, just know you run that risk.
Peter OsborneHOST
Now, if you're eating the CoA, as we mentioned, you can eat the CoA too.
Peter OsborneHOST
And its functions are so central to human biochemistry, one of the most important.
Peter OsborneHOST
If you look at all of its different core functions, number one, it builds a compound known as coenzyme A.
Peter OsborneHOST
And we'll talk about that compound in just a minute.
Peter OsborneHOST
Stay with me.
Peter OsborneHOST
I would argue that this vitamin, like I said before, so important, one of the most important overlooked and dismissed of all the vitamins.
Peter OsborneHOST
So let's take a look at this diagram.
Peter OsborneHOST
So there's a central compound that our bodies produce called CoA or coenzyme A. It's this one right here in the middle.
Peter OsborneHOST
Now coenzyme A cannot be produced without vitamin B5.
Peter OsborneHOST
So it's not as rare as we've been told, and its functions are so central to human biochemistry, one of the most important.
Peter OsborneHOST
If you look at all of its different core functions, number one, it builds a compound known as coenzyme A, and we'll talk about that compound in just a minute.
Peter OsborneHOST
Stay with me, I'll show you how central it is to all of human energy and metabolism.
Peter OsborneHOST
It is very critical for turning your food into energy.
Peter OsborneHOST
So you got to get cholesterol so that you can get to steroids like testosterone and estrogen and progesterone.
Peter OsborneHOST
So pretty core important functions.
Peter OsborneHOST
I would argue that this vitamin, like I said before, so important, one of the most important overlooked and dismissed of all the vitamins so let's take a look at this diagram so there's a central compound that our bodies produce called coa or coenzyme a it's this one right here in the middle now coenzyme a cannot be produced without vitamin b5 so this is a b5 dependent process But once you get coenzyme A, if you look at all these dark arrows pointing to all these different functions, I'm going to let you screen capture this and you can go back.
Peter OsborneHOST
Those of you who are biochemistry geeks and you want to geek out on this diagram, we'll also have this diagram in the show notes.
Peter OsborneHOST
This is how your body basically breaks those drugs down and gets them out of your systems or detoxifies them.
Peter OsborneHOST
So acetylation requires CoA, which is B5, right? So you can't do that without that.
Peter OsborneHOST
So if you're taking high doses of certain medications that drive up acetylation, you can develop lupus as a result of vitamin B5 deficiency.
Peter OsborneHOST
So this is, again, this is this doctor's thought process on it.
Peter OsborneHOST
And so what he's done in many clinical patients in practice is he's given high doses of vitamin B5, mega doses of B5, 10 grams, 10,000 milligrams or 10 grams per day for replenishment to get CoA levels back up because they've been bombarded by the medication that was taken.
Peter OsborneHOST
But in females especially, because women are much more apt to develop lupus, there's definitely a gender bias for women.
Peter OsborneHOST
And one of the reasons why is women make so much more hormone than men.
Peter OsborneHOST
So a lot of these women that are, I say women because most of the people with lupus are women, but what do they put on? They're put on steroids.
Daniel J. GuerraHOST
So you understand critical micellar growth, those concentrations are necessary to mediate the trafficking of lipids with such moieties as acyl-CoAs.
Daniel J. GuerraHOST
And those coenzyme A fractions, as you know, do not penetrate the membrane.
Daniel J. GuerraHOST
So I want you to keep in mind how fatty acids are linked to glycolysis because they are because of the critical micellar concentrations of acyl-CoA associated with medium chain and sometimes a longer chain fatty acids.
Daniel J. GuerraHOST
This is a biophysical phenomenon, which is also playing a significant role in allosteric regulation.
9 MINS LATER
Daniel J. GuerraHOST
What are those oil droplets composed of? Triacylglycerol.
Daniel J. GuerraHOST
And those triacylglycerol molecules can be hydrolytically metabolized to free fatty acids.
Daniel J. GuerraHOST
Those free fatty acids will be esterified to coenzyme A, generating acyl-CoA pools, the most common storage form of triacylglycerol in these cells.
Daniel J. GuerraHOST
is palmitoylated triacylglycerol.
Daniel J. GuerraHOST
In the eukaryotic mammalian cell, beta-oxidation of fatty acids occur in the mitochondrion, while biosynthesis of fatty acids occur in the cytoplasm.
Daniel J. GuerraHOST
So for beta-oxidation, you start off with a fatty acyl-CoA.
Daniel J. GuerraHOST
And this is a CoA where there is an acyl group carrier mechanism that activates that carbonyl so that these reactions will occur with enzymatic activity.
Daniel J. GuerraHOST
The first reaction, FAD, is the electron acceptor.
Daniel J. GuerraHOST
So FAD goes to FADH2 that generates enoyl CoA.
Daniel J. GuerraHOST
Then Water is added.
Daniel J. GuerraHOST
And what occurs here is 3L-hydroxyacyl-CoA is generated.
Daniel J. GuerraHOST
So now you have an L-beta-hydroxyacyl group.
Sam SmithHOST
So beta oxidation starts in the cytoplasm of a cell.
Sam SmithHOST
A fatty acid molecule must be activated by adding a CoA group to it.
Sam SmithHOST
So when a CoA group is added to fatty acid, it becomes acyl CoA.
Sam SmithHOST
And the enzyme that does this is called acyl-CoA synthetase.
Sam SmithHOST
And this process of activating the fatty acid requires ATP.
Sam SmithHOST
All right, so once this fatty acid is activated, it's ready to be oxidized in the mitochondria.
Sam SmithHOST
And that's exactly what the carnitine shuttle does.
Sam SmithHOST
The carnitine shuttle begins with a mitochondrial membrane protein called carnitine palmitoyltransferase 1 or CPT1.
Justin StellmanHOST
It's also responsible for proper hair growth due to its part in cell division and hair follicle and gives hair proper moisture as well as it has anti-inflammatory properties, protects, and has moisturizing abilities regulating the function of the sebum glands and accelerates the creation of melanin.
Justin StellmanHOST
So products rich in B5 are Pantene, Pantanol, and Coenzyme A are mushrooms, cauliflower, liver, eggs, baking yeast, whole grains, beans, milk, and green leafy vegetables.
Justin StellmanHOST
So B5 is definitely a part of my stack as well as B12.
Justin StellmanHOST
So I'm going to be doing this myself.