Clindamycin

So meningitis is the big sort of caveat there that's going to be a little bit different.

Bone and joint infections can also be a little bit weird too, because those patients will often get started on something like clindamycin or cefazolin or clindamycin and cefazolin, not ceftriaxone, because we're targeting staph aureus and group A strep and stuff.

Clindamycin will have decent pneumococcal coverage.

And if you get a culture from a synovial fluid, you can always alter your therapy if you need to.

And I imagine we're getting infectious disease on pretty quickly for some of those more complicated and challenging cases to make sure that we've got the right decisions, especially in those zero margin cases.

These guidelines specifically note Tigacycline is an addition to anti-C. diff infection antibiotic therapy.

Clindamycin is given a strong recommendation by IDSA to be added to penicillin for treatment of documented group A strep necrotizing fasciitis.

UK guidelines for MRSA pneumonia give a weak recommendation to consider the addition of toxin-inhibiting agents such as clindamycin or rifampicin.

And while not specifically mentioned in guidelines, linazolid also has evidence that suggests it's beneficial as adjunctive toxin therapy for strep bloodstream and skin infections.

The AGHP review gives the following dose recommendations for antitoxin therapy.

Clindamycin when used for staph or strep toxic shock syndrome given at a dose of 600 to 900 milligrams IV every eight hours for two to four days.

Linazolid when used for staph or strep toxic shock syndrome given at a dose of 600 milligrams IV or PO every 12 hours for two to four days.

and tigacycline when used for severe C. diff infection given at a dose of 100 mg IV times 1, followed by 50 mg IV every 12 hours for the duration of C. diff treatment.

Clindamycin and penicillin so Clindamycin one fifty three hundred penicillin three hundred then comes the frequency both of them are QID or six hours then comes the dosage is three hundred to six hundred for penicillin for Clindamycin it is one fifty to three hundred.

What about the kid dosage for penicillin it is six to twelve on the other hand for Clindamycin it is two to six.

For the solution availability penicillin is twenty five and sixty per ml Clindamycin is seventy five by five.

This amoxicillin and metronidazole amoxicillin is available as one twenty five two hundred fifty five hundred metronidazole is two fifty five hundred amoxicillin both amoxicillin and metro is TID so that is six to no that is eight hours it's not two hours it's it's not a range it's just one hour so eight hours or TID.

Then similarly the dosage of this is maximum that can be given is two fifty to five hundred.