Clarithromycin

He was recently prescribed clarithromycin, and several days later develops diffuse muscle pain, weakness, and dark urine.

What do you think happens here? That's right.

Clarithromycin can increase simvastatin levels and cause severe muscle toxicity.

Very good.

Simvastatin is metabolized through CYP3A4 enzyme, and clarithromycin inhibits that enzyme.

Next, its dosage is that we can give two fifty to five hundred a day or thousand, two of five hundred.

Clarithromycin is DID.

Or else when giving the thousand, it is OD.

OD or two of thousand and five hundred.