Citric acid cycle

Not to mention, the dependency on just basic nutrients that support the mitochondria.

There's this thing in the mitochondria called the Krebs cycle that maybe you've learned about, and I'll guarantee rarely anyone understood it back then.

You'd have to really play around with it to really grasp or wrap your wits around it because it's a very complex machinery.

But the simplicity is your body's turning food into energy using oxygen.

But I looked at nicotinic acid, and also B3 and nicotine, and it doesn't just cross over.

It does not increase something called NAD, which helps you transport electrons through the Krebs cycle.

So I'm not a fan of it, but there's other ways to get healthy.

All right, very good.

And then there's mitochondria markers, so for your energy organelles.

So it looks at the key areas through the Krebs cycle, which produces your ATP, your energy.

So markers that will show deficiencies that could be like CoQ10 or ubiquinol, key B vitamins, carnitine, those sorts of things might be the fixes in there, but it'll identify areas where the mitochondria or the Krebs cycle might be falling down.

Then it looks at key nutrients.

So it's pretty hard to assess some B vitamins in the body.

But if you don't have the key co-factors like the vitamins, minerals working with them, then you get these steps going around to create molecules in the body so we operate well and feel good.

But those steps fall over or they don't create what they're supposed to properly.

And then that's when you start getting symptoms like the Krebs cycle from energy with your mitochondria or neurochemistry.

And that urea then is ultimately, as I said, excreted, right? Okay.

So if you think about it, we're coupling the tricarboxylic acid pathway with the urea cycle, where fumarate, will re-enter the TCA, and the urea cycle will be fed by the TCA via transaminase reactions, aspartic acid.

Okay? So that's how you're generating the intermediates between the TCA and the urea cycle.

And ultimately also glucose can be generated.

So gluconeogenesis can play a role and can be functionally aided by the urea cycle.

When cells are stimulated in limiting glucose, So even though a loss of AMPK can restore some functions in glucose-restricted T cells, the cells don't fully initiate metabolic adaptation that would be necessary to recover full plenum ATP levels.

So in vivo, AMP kinase alpha-1 deficient T cells have a diminished mitochondrial respiration, there's an increased flux of glutamine into the mitochondria, which you know is the anaplerotic introduction of carbon from glutamine to glutamate via transamination out of alpha-ketoglutarate directly into the TCA.

And so the ATP to AMP ratios are all then funneled to those events in the mitochondria.

And therefore, when this occurs, there's a failure to proliferate And once that failure to proliferate is fully saturated, even the T cell function itself, its effector function starts also to diminish.

And then therefore ultimately will exhaust the glucose.

And yeah, they'll turn over just because of such events as senescence and polyubiquitinylation of the proteins.

which make up all of the intermediary metabolic activities, such as glycolysis, oxyappendylsphosphate shunt, beta-oxidation of fatty acids, transamination of fatty acids, the TCA cycle electron transport trend, and ultimately also the removal of reactive oxygen.

All right.

Inside your muscles, what generates the energy is the mitochondria.

I don't know if you've ever taken biochemistry before, but even if you have, most people still are still confused on what this Krebs cycle is all about.

The Krebs cycle is like an assembly line of little things that occur inside the cells, inside the mitochondria.

And your body is taking this food and transforming it into energy as ATP storage.

and it's turning food into the building blocks so you can build up body tissue and body chemistry so that's simply what the krebs cycle is but what a lot of people don't know is when you go through the different points or stages on this assembly line you need certain nutrients for that to work if you are low in these certain nutrients you get a bottleneck.

It just stops working, and that's going to affect the Krebs cycle, and that's going to back up your energy and your biochemistry of someplace which is occurring somewhere in the body.

There's actually a way to test it, which I'm going to do some videos about, but the point is you want this entire assembly line to be free-flowing without any micronutrients missing.

I'm talking about iron, b1 b2 b3 b6 b5 about magnesium i'm talking about manganese and another nutrient called coenzyme q10 right that's in the mitochondria as well well guess what when you have red meat you don't have to worry about it it's all in there if you have a high quality like grass-fed beef or hamburger whatever all of those cofactors everything i talked about is in a package it's inside there you have everything you need to build muscle and repair the muscle these people that are cutting out red meat they're maybe doing chicken breasts which has way too many omega-6 fatty acids and it's definitely of lesser quality and so is like plant-based protein that's like really low on the list whereas sometimes people think those are clean proteins to help you they're not there's other things you can do too you can do eggs and those are good but if you do eggs make sure they're not raw because the raw can deplete your biotin and it's not nearly as bioavailable as the cooked eggs another protein that's not bad is a real good high quality cheese okay think about it where does cheese come from it comes from milk in nature when does an animal need milk when they're growing why because milk has a lot of growth factors to help muscle building and so a little bit of cheese can do wonders on your muscles for growth and increasing muscle size Just don't do the low quality cheeses.