Citalopram
MedicationWikipedia
68
MENTIONS
33
EPISODES
28
PODCASTS
Search complete. 68 mentions across 33 episodes found for "Citalopram".
Oct 29, 2026
Ken BerryHOST
Leg cramps are a symptom that I often hear.
Ken BerryHOST
Celexa, which is a serotonin reuptake inhibitor, can... tend to increase your risk of leg cramps.
Ken BerryHOST
So if you're on Celexa or any of the SSRIs, you might talk to your doctor about decreasing the dose or changing to something else or just weaning down and stopping if you're having leg cramps.
Ken BerryHOST
Now, number, well, let me ask you this.
Ken BerryHOST
If you've ever been on a medication that you think caused leg cramps, put in the comments down below what the name of that medicine was and if the leg cramps stopped.
Mollie AdlerGUEST
I was on like, can't even remember.
Mollie AdlerGUEST
I think it was, um, Citalopram or something.
Mollie AdlerGUEST
And I was still trying at that time.
Mollie AdlerGUEST
I had a new psychiatrist here in Austin.
Anthony DukGUEST
SSRIs and THC are a little bit easier to endure from a pharmacologic standpoint because they're not really at crossroads with their mechanisms of action.
Anthony DukGUEST
One of them is raising serotonin, SSRIs like Zoloft, Celexa, Prozac, Paxil, Effexor.
Anthony DukGUEST
But those medications, when they raise serotonin, they don't really have much of a crossover effect with the Delta-9 THC, the prefrontal cortex issues.
Anthony DukGUEST
But when stimulants are involved, stimulants and THC directly oppose each other.
James GreenblattGUEST
For too many years, the psychiatric community completely ignored what happens when you stop these medications.
James GreenblattGUEST
I call it withdrawal, they call it discontinuation syndrome, and it was just kind of eye-opening when I had two people stop the same medicine, it was Celexa, and one person did it fine, and the next one had these intractable, you know, brain zaps and suicidal thoughts.
James GreenblattGUEST
And I realized what's not the medicine, it's what's going on in that individual.
James GreenblattGUEST
And once we do the functional testing, we replete the D and the B12 or the amino acids, we can safely withdraw someone from these
37 MINS LATER
James GreenblattGUEST
Because I'm quite convinced if we do these functional medicine tests before someone stops their medication, we can completely eliminate those withdrawal symptoms.
James GreenblattGUEST
And it was just kind of eye-opening and probably 10, maybe 15 years ago when I had two people stop the same medicine.
James GreenblattGUEST
It was Celexa.
James GreenblattGUEST
And one person did it fine.
W. Bryan HubbardGUEST
But as she heard the testimonies in Kentucky when I was running the commission, we had hearings to have people come in and talk about it, to inform the people at home as to what this was and what it could do and why it was worthy of taking a little bit of our settlement money to try to have it developed as a drug.
W. Bryan HubbardGUEST
She said, you know, I think if for no other reason, I want to see if I can come off of my Celexa.
W. Bryan HubbardGUEST
She had had a mood disorder that she developed after her son was born in 2001.
W. Bryan HubbardGUEST
She went into a profound postpartum depression.
W. Bryan HubbardGUEST
And when she would have these episodes, she could be a danger to herself and others in my face.
W. Bryan HubbardGUEST
You know what I'm saying? Mm-hmm.
W. Bryan HubbardGUEST
So before we went to the clinic in 2023, they said, she's gonna have to come off of her Celexa for five days because if she's taking it, when she gets down here, it will blunt the effect.
W. Bryan HubbardGUEST
And Theo, I had just like broke into a cold sweat immediately.
CarlosHOST
So Zoloft, Prozac were, but not Paxil.
CarlosHOST
Now we head over to Solexa, Citalopram.
CarlosHOST
It's FDA approved for adult major depressive disorder.
CarlosHOST
Also prescribed off-label for certain anxieties.
speaker_2HOST
Which medication should you choose? These are important questions.
speaker_2HOST
So let's look at the six major SSRIs, fluoxetine, also known as Prozac, sertraline, Zoloft, paroxetine, Paxil, and there's different types of Paxils, citalopram, which is Celexa, citalopram, Lexapro, and fluvoxamine, which is Luvox.
speaker_2HOST
Those are the common U.S. brand names.
speaker_2HOST
SSRIs inhibit the serotonin transport known as SERT, preventing serotonin reuptake into presynaptic neurons.
speaker_2HOST
So you'll see sexual dysfunction and discontinuation symptoms.
speaker_2HOST
It is generally avoided in older adults when suitable alternatives exist.
speaker_2HOST
Celexa requires attention to dose-dependent QT interval prolongation in the heart.
speaker_2HOST
The FDA recommends a maximum of 20 milligrams daily for adults older than 60 and certain other high-risk groups.
CarlosHOST
So...
CarlosHOST
Let's look at the six major SSRIs, fluoxetine, also known as Prozac, sertraline, Zoloft, paroxetine, Paxil, and there's different types of Paxils, citalopram, which is Celexa, citalopram, Lexapro, and fluvoxamine, which is Luvox.
CarlosHOST
Those are the common U.S. brand names.
CarlosHOST
SSRIs inhibit the serotonin transport known as SERT, preventing serotonin reuptake into presynaptic neurons.
CarlosHOST
Suspected serotonin syndrome requires immediate discontinuation of serotonergic agents under urgent medical management.
CarlosHOST
The discontinuation syndrome, abrupt discontinuation can produce dizziness, nausea, insomnia, anxiety, and electric shock sensations.
CarlosHOST
paroxetine or paxil is particularly associated with discontinuation symptoms particularly because of its relatively short half-life remember prozac has a long half-life so it has much lower risk there's a minimum five-week washout required when switching from fluoxetine to an maoi because of its long half-life which is a little different some of the other ones are about two to three weeks So if you have a 67-year-old patient with depression and a history of prolonged QT interval requires antidepressant treatment, which medication warrants particular caution? A, Zoloft, B, Celexa, or C, Prozac? If you said B for Celexa, citalopram, you are right.
CarlosHOST
If you also were curious about what is the QT interval, The QT interval is a measurement on the ECG electrocardiogram that reflects the total time required for the heart's ventricles to electrically activate and then recover.
Leticia SheaGUEST
So certain medications, I'm going to go back to, well, I'm going to do a different one.
Leticia SheaGUEST
Zoloft, not Zoloft, but Lexapro, Escatalopram, or the original form of that, Citalopram or Celexa, they are really, really dependent on the CYP2C19 Pac-Man.
Leticia SheaGUEST
And so if an individual is a poor CYP2C19 Pac-Man, poor metabolizer, they're going to take, an individual with that is going to take one dose of that and feel a lot more.
Leticia SheaGUEST
It's going to be like they're taking twice as much.
CarlosHOST
Examples, of course, include sertraline, which is Zoloft, fluoxetine, Prozac, cytotilopram, and paroxetine.
CarlosHOST
So you've got Celexa, Lexapro, Paxil, additional ones.
CarlosHOST
Although transporter inhibition occurs relatively quickly, meaningful antidepressant improvement often develops over several weeks.
CarlosHOST
Adaptation and receptor signaling and neural circuits are believed to contribute to the delayed therapeutic response.
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