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Christian Howell
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Sep 24, 2026
Don't Use The D Word With Christian Howell
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20:57

Liz MoylesHOST
Tell us how this amazing idea, kind of two people collided with one half of the equation, each of them, and suddenly it was like, wow, that's amazing.

Christian HowellGUEST
To your point about using analogies, I'll use one here, which is we think about orchestration all the time and coherence.

Christian HowellGUEST
It's amazing how much orchestration had to happen for this technology to come forward.

Christian HowellGUEST
The first principle challenge of Cognito is that at times it seems too simple to be plausible.

Christian HowellGUEST
But we do think that simplicity now actually becomes a tailwind because it makes it easier for patients and prescribers to kind of understand what's happening.
11 MINS LATER

Liz MoylesHOST
You know, is there anybody who stands out in your mind, your memory, any one of these patients when they start their brain lighting up?
How Health Economics Drives Medtech Growth with Christian Howell, CEO of Cognito Therapeutics
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Christian HowellGUEST
So we're a neurotechnologies company that is really pioneering an entirely new type of therapy.

Christian HowellGUEST
And so what we're using is we're using sensory stimulation to drive activity in the brain that... generates endogenous biology that is incredibly important to preserving brain structure and brain function.

Christian HowellGUEST
And so the way that the therapy works is we use sensory stimulation, light, sound, even touch, to drive a persistent and consistent activity level in the brain.

Christian HowellGUEST
It prompts biology that is incredibly important to things like synaptic resilience and myelin production and reducing neuroinflammation.
7 MINS LATER
Daniel Gross’s AGI Trades, SpaceX’s $1.75T IPO, Google Silences Sweeney | Mark Gurman, Dan Primack, Cameron McCord, Max Haot, Christian Howell
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153:17Christian HowellGUEST
And that when the brain is at a particular activity rate, um, that they call the gamma bran- uh, gamma band, when the neurons are firing north of 40, uh, hertz per second, then what you see is you see this sort of profound biology that is driven, that helps drive synapses and myelin and, and really preserve brain structure and brain function.
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153:38Christian HowellGUEST
And they then learned that you could, you could use an external stimulation to drive that level of activity, and actually if you stimulated the visual and the auditory cortices, that would give you the most profound sort of response.
7 MINS LATER
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160:34Christian HowellGUEST
'Cause I get to see this really interesting science get delivered to families that need it desperately.
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160:40Christian HowellGUEST
And, and as much as I'd love for your story to be, you know, unique, and it's unique for you guys, uh, there's not a day that I don't run into people that say, you know, "My mom," or "My dad," or "My aunt," or "My uncle," or...

