Chlordiazepoxide

We'll go there.

We're gonna give you some Librium, help you withdraw.

You're gonna get your daily massages.

You're gonna be, have your chefs."

So I did three days detox.

I had Librium tablets and I think it was worse than being drunk.

My body was shaking.

I got sweats on.

And then he just had to make sure that I was going through everything right.

So taking the Librium.

Your GP has to refer you to the centre.

Yeah,

So let's go back to 1955.

A chemist at Hoffman LaRoche was synthesizing compounds, basically looking for new tranquilizers, and just stumbled upon Chlordiazepoxide.

Which hit the market as Librium.

Exactly.

And the second topic is the approval of Symtrio for ADHD.

So the FDA approved Symtrio, the brand name for centinafidine for ADHD in adults and kids ages six and up.

And what makes this notable is the mechanism.

So it is a I will note this is actually a first-in-class agent, but perhaps more importantly, it's a non-stimulant with low expected abuse potential rather than one of the Schedule II stimulants that we're typically used to using.

He noticed it had a strange calming muscle relaxant effect on lab animals.

They'd go limp, but they'd stay conscious and alert.

So they kept tinkering with the chemistry and landed on Microbimate, which got FDA approval in 1955 and hit the market under two brand names, Milltown and Equinil.

And then it just exploded.

Yeah.

Also, Librium.

Which I also googled and that is a benzo.

So also a drug you out of your mind type medication.

I had lost a lot of blood.

I happened to have my cell phone with me, so I called myself an ambulance, in which they treated me for my injury and detoxed me safely with Librium.

Today, I am alcohol-free and happy.

As correctly expected, there was some hard toll to pay for the excess that I logged in.

And I think I want to start just by asking when inevitably you must be asked questions almost every day thereabouts on that topic of, so are benzodiazepines all good or all typically respond to such initial questions? Okay,

we've had benzodiazepines since the 1960s, with Librium being the first of the drugs.

They revolutionized the treatment of anxiety disorders.

Prior to them, we had only barbiturates and mill town type drugs, which were much more dangerous, had many side effects.