CHEK1

It was published in Nature Cell Biology.

The title is SARS-CoV-2 Infection Induces DNA Damage Through CHK1 Degradation and Impaired 53BP1 Recruitment and Cellular Senescence.

So this study found that there are three mechanisms through which the presence of the spike protein, in this case they're calling it a SARS-CoV-2 infection, interferes with DNA repair mechanisms.

Those three are, number one, ORF6 and NSP13.

They degrade the DNA damage response kinase, CHK1, through proteasome and autophagy.

CHK1 loss causes DNTP shortage.

I'm reading from my notes.

I don't have all this memorized.