Charles Brenton Huggins

Okay, so the reason that the Dunning tumor and, you know, its reports was so important is that that, that prostate tumor that developed in that Copenhagen rat had the histology, biochemical properties, et cetera, of what we saw in humans.

And please understand that, that at the time when Charles Huggins found the hormone dependence of prostate cancer, that the prostate cancers needed, uh, testosterone to grow, the androgen to grow, men would have widespread skeletal metastases.

They were crippled in bed, dying.

And when they had orchiectomy, when they were castrated, no more t- no more tumor.

Hormone therapy, foundational.

It's been foundational since Charles Huggins' first report.

The AR pathways, which we'll talk about extensively, the o- oral ARPIs.

Then we have a chemotherapy bucket, and then we have these, like, molecular, kind of the cool new, you know, kids on the block, these molecular-selected therapies, the PARPs, gavacertib, you know, the PTEN-deficient agents.

It started in 1941.

I just today got from my colleagues the first paper where it was introduced by Charles Huggins, the father of hormonal therapies.

I'm a Canadian.

I'm up here in Vancouver in Canada.