cell
208
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28
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Search complete. 208 mentions across 28 episodes found for "cell".
Nov 8, 2026
Ross WalkerHOST
And this tells us very little about what's happening in the liver, the brain, the kidneys, or even the heart.
Ross WalkerHOST
But a remarkable study published in the journal Cell on the 15th of October this year has started to fill that gap.
Ross WalkerHOST
So researchers at the Salk Institute in California took young male and female mice, let half of them run voluntarily on a treadmill or a wheel.
Ross WalkerHOST
for eight weeks, while the other half stayed sedentary and then examined 22 different tissues throughout the body.
Erin HarrisHOST
But first, I want to talk a little bit about manufacturing.
Erin HarrisHOST
And we've talked about this in article form on Cell and Gene, but I want to hear your take on the fact that you know, manufacturing is treated sometimes as an afterthought in cell and gene therapy development.
Erin HarrisHOST
And such that, how can cell and gene therapy sponsor companies kind of change what that looks like? How could they be making better decisions? And what are the most common mistakes you see developers making before they reach the clinic?
Ali PashazadehGUEST
Okay, so on the point of manufacturing, I'd say 95% of cell and gene therapy companies that I've seen fail have failed on the manufacturing.
22 MINS LATER
Erin HarrisHOST
Of course.
Erin HarrisHOST
And thank you to listeners for tuning in.
Erin HarrisHOST
We will see you next time right here on Cell Engine, the podcast.
Erin HarrisHOST
And we'll talk to you soon.
Jason GoldsmithHOST
We're always looking for feedback on how podcasts can be improved and for suggestions on guests.
Jason GoldsmithHOST
Today, we have Dr. Dan Littman from the NYU Grossman School of Medicine on the podcast to talk about his research on T-cell development and microbiome immune interactions.
Jason GoldsmithHOST
We've also got our usual roundup of recent highlights and immunology news coming up.
Jason GoldsmithHOST
But
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speaker_4GUEST
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Mohamed ImamHOST
To address this specific access paradox, the Centers for Medicare and Medicaid Services, CMS, launched the Cell and Gene Therapy Access Model in January 2025.
Mohamed ImamHOST
This covers approximately 84% of Medicaid beneficiaries with sickle cell across 33 states, and it operates as an outcomes-based agreement.
speaker_4GUEST
Yes, it's a very novel approach.
Ryan ReynoldsADVERTISER
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John GarrettHOST
What if one of the most exciting frontiers in regenerative medicine involves something our bodies already do every day? Cells communicating with each other.
John GarrettHOST
Think about it.
John GarrettHOST
Every time we heal from an injury or recover from physical stress, there's an extraordinary amount of communication happening behind the scenes.
John GarrettHOST
Cells release chemical signals that help coordinate inflammation, repair, and recovery.
John GarrettHOST
And scientists are learning more about those messages with growth factors, peptides, and extracellular vesicles, and exploring whether they could open new possibilities in regenerative medicine.
John GarrettHOST
That's what we're diving into today.
Ross WalkerHOST
When the endothelium is damaged, that's the first step on the road to heart attack or stroke.
Ross WalkerHOST
So researchers from Stanford University published in the journal Cell showed that THC, the main psychoactive chemical in cannabis, binds to a receptor called CB1 on the cell linings, these blood vessels, triggering inflammation and oxidative stress.
Ross WalkerHOST
And in animal studies, accelerated atherosclerosis, which is the progressive buildup of fat and inflammation and calcium in the wall of your arteries.
Ross WalkerHOST
Remarkably, the blood vessel lining turned out to be more sensitive to THC than the heart muscle itself.
Paul MasonHOST
If you change what you feed it, the microbes best suited to that new food will out-compete the rest.
Paul MasonHOST
So there was a 2022 study that was published in Cell, and it gave 120 adults sweetness for two weeks.
Paul MasonHOST
And all four of the sweetness that they tested changed the gut bacteria.
Paul MasonHOST
So yes, sweetness definitely changed your gut.
John GarrettHOST
Welcome back to Peptides Explained, where we break down the science behind peptides, biological signaling, regenerative medicine, and emerging therapies without the hype.
John GarrettHOST
When most people hear the term regenerative medicine, they immediately think about stem cells.
John GarrettHOST
The idea that we can introduce new cells into the body and potentially repair damaged tissue has generated tremendous scientific interest.
John GarrettHOST
But what if the cells themselves aren't the entire story? What if much of their biological activity comes from the messages they send to other cells? We're talking about growth factors, cytokines, peptides, extracellular vesicles, and an entire communication network that helps regulate inflammation, tissue repair, and cellular behavior.
John GarrettHOST
My guest today is Sanjiv Lal, founder of Cell Factor and co-founder of Regen Therapy.
John GarrettHOST
Sanjeev is working in the emerging field of cell-free regenerative technologies, specifically using signaling material derived from perinatal tissues.
Sanjiv LalGUEST
We don't do that kind of stuff.
Sanjiv LalGUEST
That's not where, that's not where it sits.
Mark HymanHOST
But first, let me tell you about the second study, which in some ways was even more dramatic.
Mark HymanHOST
That study published in the journal Cell, tested much higher doses of resveratrol in mice.
Mark HymanHOST
These doses were 18 times higher than those in the first study.
Mark HymanHOST
That's 400 milligrams per kilogram of resveratrol, equal to about 360 capsules daily of resveratrol for a 130-pound person.
RonHOST
How does this affect the cell? And as I've said, we tend to discuss health in terms of diseases, high blood pressure, diabetes, heart disease, neuropathy, dementia, whatever, chronic fatigue, they matter.
RonHOST
But understanding the processes that contribute to that dysfunction matters a lot.
RonHOST
Cells depend on properly functioning membranes.
RonHOST
They depend on proteins, mitochondria, enzymes, and signaling systems.
RonHOST
And this goes back to our talks on linoleic acid and adulterated omega-6s.
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