CD135

So potentially venetoclax can be used in combination with drugs that target components of the MIB complex.

Another important gene that MIB regulates, especially in ALL, is FLT3.

And FLT3, again, is a gene that it's a cell surface receptor.

And there are drugs out there like quartsinib.

Sorry, I always mispronounce that one.

But there are FLT3 inhibitors, let's put it that way, that can target overexpression of FLT3.

So those are two key genes that MIB regulates.

What stops MIB from setting up these enhancer gene interactions in normal cells?

If you're over the age of 60, you could be NPM1 positive.

No FLT3 patients at all.

And if you're over 60, you had to be, you know, fit enough for 7 plus 3 or CPX351 because that's the intensive chemo arm at 7 plus 3 or CPX351.

And in the investigative arm is ACE of N, same dosing as the Valley A study.