PROM1

Being able to use this stress test to determine which kidney would be better to take out to improve patient outcomes for living donors.

We find PROM1 is a major component of intratubular cast.

That means PROM1 is secreted from tubules, but it has never been reported.

mammalian kidneys have very limited regeneration capacity.

So we turn to aceratose.

And in this study, I analyzed visually, but I analyzed all the markers.

And one of our finding results of these 42 markers, I see three key components of casts at protein level.

So that's uromodulin, which was already known, And also PROM1 and IGF-BP7, which are kind of not described before.

They don't a hundred percent confirm it with the fatty acids themselves, but they point to it, and then we'll be getting into that with ketones and then some, uh, even more telling studies after that.

But we're gonna start with this study from twenty twenty-four titled "Fatty acid oxidation is critical for the tumorigenic potential and chemoresistance of pancreatic cancer stem cells." And they stated, "Treatment with palmitic, oleic, and linolenic fatty acids notably augmented the self-renewal and chemotherapy resistance of CD133 positive." Conversely, inhibitors of fatty acid uptake, storage, and metabolism reduced cancer stem cell populations both in vitro and in vivo.

Mechanistically, inhibition of fatty acid metabolism suppressed oxidative phosphorylation activity, inducing energy depletion and subsequent cell death in these cancer stem cells.

These are pancreatic cancer stem cells.