Carcinoembryonic antigen
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Search complete. 27 mentions across 13 episodes found for "Carcinoembryonic antigen".
Oct 14, 2026
Jay ChaplinHOST
They are almost exclusively, if not exclusively, expressed by cancer cells.
Jay ChaplinHOST
And some of them don't even have numbers like CEA, carcinoembryonic antigen, CEA.
Jay ChaplinHOST
You just get letters with that, no numbers.
Jay ChaplinHOST
Those are all proteins that are made by cancer cells.
6 MINS LATER
Jay ChaplinHOST
So, I suspect that you wrote that before I talked about the blood work.
Jay ChaplinHOST
So minimal residual disease testing, that's usually Signatera, that's circulating tumor DNA tests or circulating tumor cell tests.
Jay ChaplinHOST
And again, the reason for that is that they are substantially more expensive than the cancer antigen tests or CEA, PSA, that type of thing.
Jay ChaplinHOST
They have much more noise and bounce in their values.
Marcia CicconeHOST
So if we have women in their 20s, 30s, you know, it might be worth adding those tumor markers just because they're younger.
Marcia CicconeHOST
And so I think those are important ones to consider when you have a younger patient in their 20s and 30s.
Marcia CicconeHOST
We tend to also send CA-19-9s and CEAs because they can be elevated in different tumors, maybe mucinous tumors, sometimes an amyotroid.
Marcia CicconeHOST
Not every mouth on the ovary is From the ovary ovarian cancer, you could have some other kind of cancer that's metastasized to the ovarian.
Marcia CicconeHOST
And then for patients like you described that have symptoms of hormone imbalances, overproduction of testosterone, abnormal bleeding or postmenopausal bleeding.
Richard LeeGUEST
And, um, yeah, for, for many years, right, in this metastatic disease setting, we, you know, we would follow serum tumor markers in addition.
Richard LeeGUEST
But, you know, the problem with tumor markers or tr-the traditional tumor markers, whether it's CEA or CA fifteen dash three or CA twenty-seven, twenty-nine, is that sometimes the readout from tumor markers can be pretty variable, and they don't always really track well in linear fashion-
Thomas BlomHOST
Mm.
Richard LeeGUEST
-what the state of somebody's cancer is.
Thomas BlomHOST
... do you think that, you know, blood, uh, or standard blood markers, CA-27-
Richard LeeGUEST
Yeah
Thomas BlomHOST
... twenty-nine, fifteen three, CEA-
Richard LeeGUEST
Yeah
Diane RogersGUEST
Okay
Barbara WhitlowGUEST
... right now, but I know that they do, do do the, um, CEA levels.
Diane RogersGUEST
Okay.
Barbara WhitlowGUEST
That's what they do.
Barbara WhitlowGUEST
That's what they do.
Diane RogersGUEST
Yes, okay.
Barbara WhitlowGUEST
The CEA level to determine, and then based on how high that level is-
Diane RogersGUEST
Mm
Nasha WintersGUEST
And you want to make sure you reestablish a bounty of healthy cells as quickly as possible so that any lingering, because there always will be, cells do not come back in and override the system again.
Nasha WintersGUEST
So if I have a patient finishing their treatment, and they have perfect scans, no evidence of disease, and their tumor markers, whether it's breast, like CA-15-3, CA-27-29, CEA, so the most common breast cancer markers, if they're all perfect, everyone is celebrating at the oncology office.
Nasha WintersGUEST
But if I see that trifecta are all out of range, I'm not celebrating.
Nasha WintersGUEST
In fact, I know it's a matter of days, weeks, or months before that cancer is back bigger and louder than ever.
Nasha WintersGUEST
What I tell folks is that's actually just the beginning because those life-saving standard of care therapies, they do a great job at harvesting out the cancer cells, but they also do a great job at harvesting out the healthy cells, and you wanna make sure you reestablish a bounty of healthy cells as quickly as possible so that any lingering, 'cause there always will be, cells do not c- come back in and override the system again.
Nasha WintersGUEST
So if I have a patient finishing their treatment and they have perfect scans, no evidence of disease, and their tumor markers, whether it's breast, like CA 15-3, CA 27-29, CEA, so the most common breast cancer markers, if they're all perfect, you know, everyone is celebrating at the oncology office.
Nasha WintersGUEST
But if I see that trifecta are all out of range, I'm not celebrating.
Anna CabecaHOST
No.
Feng WangGUEST
And we do have a lot of new targets now in clinical trials.
Feng WangGUEST
So as I talked about like CMAT, CEA, CDH17, or EPICOM, also we have some new targets in immunotherapy.
Peter GoodwinHOST
And you're using these in both neoadjuvant therapy and adjuvant therapy, are you? Where do they lie?
Feng WangGUEST
Yeah, in the setting of new adjuvant or perioperative setting, actually we do like immunotherapy for a patient.
Sophie UmhoferGUEST
um, a good response.
Sophie UmhoferGUEST
It, um, had got rid of a few of the tumors and this, um, I don't know if, if, um, yours is effective, but the CEA on my blood results, um, they're a good indicator for me.
Sophie UmhoferGUEST
It was, um, When I was diagnosed, it was like in the thousands and it should be between zero and five.
Sophie UmhoferGUEST
And it had come down, the CA had come down quite a bit on that first scan as well.
Peter MichalosGUEST
They take a sample of your poop and the tumor antigen, they find it in the poop, and they can tell you whether you need to have a colonoscopy, and that can save your life.
Peter MichalosGUEST
There's even tests now, regular blood tests like the CEA test, which can test for colon cancer.
Peter MichalosGUEST
There's a blood test called alpha-fetoprotein that can check for things like testicular and liver cancer.
Peter MichalosGUEST
And, of course, they have these blood tests like Galleri and CancerGuard, which can test for up to 50 cancers.
speaker_2HOST
Because the elevated urea and creatinine provide immediate quantifiable evidence of that dehydration and the decreased glomerular filtration.
speaker_1HOST
But we also use these biochemical markers to look into the future prognostically, right? Like with CEA.
speaker_2HOST
Carcinoma embryonic antigen, yeah.
speaker_2HOST
If a patient is undergoing resection for a Dukes B-grade colorectal carcinoma, their preoperative CEA is likely elevated.
speaker_2HOST
So once the tumor is removed, we monitor that marker's half-life to see it drop back into the normal reference interval.
speaker_1HOST
And establishing that new baseline is critical because CEA isn't just a simple binary switch.
speaker_1HOST
It's a slope.
speaker_1HOST
We're tracking the trajectory.
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