Canagliflozin

In male mice, in female mice, the dose might have been too high, and that's a long story.

Canagliflozin has been found to increase maximum and median lifespan.

And then human beings, although they're approved for basically for diabetes, they reduce the sodium glucose co-transporter.

So we end up paying out more glucose.

So SGLT2 inhibitors are another class of medications, kind of the 1B of medications right now.

And they're pills, once-daily pills, and brand names are such as Jardiance, Farxiga, Invokana.

And they're really effective medications as well.

So they help your body pee out sugar through your kidneys, but the benefits are pretty impressive because they've been shown to help protect your kidneys and they've actually been shown to help reduce your incidence of heart attacks and strokes in certain populations, which is very impressive.

Fournier's gangrene of the perineum is very rare but serious.

Canagliflozin was associated with an increased risk of amputation in the CANVAS program, so examine the feet.

And they should not be used in type 1 diabetes outside specialist settings because of the ketoacidosis risk.

GLP-1 receptor agonists.