cachexia
SyndromeWikipedia
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MENTIONS
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Search complete. 8 mentions across 7 episodes found for "cachexia".
Sep 12, 2026
Shara PerryHOST
All right, let's talk about cancer cachexia and systemic illness.
Shara PerryHOST
So Pete also suggested that aspirin might protect against systemic consequences of cancer, including cachexia, immune suppression, inflammation, and tumor-associated metabolic dysfunction.
Shara PerryHOST
Cachexia is complex.
Shara PerryHOST
It's a complex syndrome.
Shara PerryHOST
It involves loss of muscle mass, weight loss, really reduced appetite, inflammation, and altered metabolism.
Shara PerryHOST
It's not simply a matter of eating too few calories.
Shara PerryHOST
It's not that cancer patients don't know how to eat.
Shara PerryHOST
Cachexia is a real thing that damages metabolism, alters it, and people have a real problem with losing massive weight during cancer treatment.
Chris CaseHOST
for anybody who wants to look it up.
Chris CaseHOST
Cachexia.
Trevor ConnorHOST
That is often, unfortunately, what kills people with cancer, not the actual cancer cells.
Trevor ConnorHOST
And cachetia is basically the cancer cells are stealing so much of the body's glucose that it starves the rest of the body.
speaker_2HOST
Exactly.
speaker_2HOST
The vaccine might be altering the tumor's actual lethality, slowing down its microscopic spread in ways that a standard CT scan just cannot detect, or, and this is a prevailing theory right now, it alters the body's cytokine environment to reduce deadly cancer side effects like cachexia.
speaker_1HOST
Cachexia, right, because most people assume advanced cancer patients pass away from the physical mass of the tumor itself, you know, crushing an organ or something.
speaker_2HOST
Right.
speaker_2HOST
But in many cases, they succumb to secondary organ failure, infection, or cachexia.
speaker_1HOST
Let's explain cachexia because it's a term thrown around a lot, but the mechanics of it are frankly horrifying.
KumarGUEST
They really are.
speaker_1HOST
Cachexia isn't just about a patient losing their appetite and not eating enough.
speaker_1HOST
It's a state of hyper inflammation.
speaker_1HOST
The tumor essentially hijacks the body's metabolism and forces it to start breaking down its own skeletal muscle.
speaker_2GUEST
That is a very accurate way to frame it.
speaker_2GUEST
Cachexia severely limits a patient's physical ability to tolerate life-saving conventional treatments like chemotherapy or surgery.
speaker_2GUEST
Of course.
speaker_2GUEST
If a patient is dealing with severe nausea or is already at risk for muscle wasting, putting them on a starvation-level diet just to force a low GKI is actively harming their chances of survival.
Valeria LopezHOST
Whether you feel it or not, it's happening.
Valeria LopezHOST
A 2025 scientific review that was led by researchers from, um, the Northumbria University, and it was published in a very prestigious journal, The Journal of, um, Cachexia, Sarcopenia, and Muscle, they found that women have around 2.6% less muscle during perimenopause and nearly 6% less after menopause than before, okay? So this means that after the whole menopausal transition is over, we get 6% of muscle loss.
Valeria LopezHOST
That's a lot.
Valeria LopezHOST
The most women unknowingly make the problem worse because they start eating less and doing more cardio when they start putting on weight, and that burns through even more muscle.
Dominic D'AgostinoHOST
And also, uh, Dr. Andrew Kuttner really did his PhD dissertation work was showing, um, the, the basis of his work was showing the anti-catabolic effects.
Dominic D'AgostinoHOST
That was published in the Journal of, uh, Cachexia and Sarcopenia.
Dominic D'AgostinoHOST
So in, like, inflammatory states and aging, uh, muscle wasting states like cachexia, ketones have a distinct advantage of having an anti-catabolic effect, preventing muscle breakdown.
Dominic D'AgostinoHOST
And that might be very relevant to someone on a GLP-1, uh, you know, maybe if they have, you know, insulin resistance or, you know, they restrict calories too much, right? They're in a calorie deficit, so they're just gonna lose muscle no matter what.