Bone remodeling

So let's talk a little bit about what osteoporosis is, what's happening, all of the science behind it, and then we're gonna go into some tools of how you can prevent it.

Okay, there's something called bone remodeling.

which is really interesting.

Actually, within your first year of life, your skeleton will 100% rebuild its entire self.

So you have an entirely new skeleton because your bone tissue is recreating itself over and over and over again.

And as you become an adult, that's like, you know, 10% a year or something like that.

So your creation of new bone, when the creation of new bone doesn't keep up with the loss of old bone, then you lose that sort of bone remodeling ability.

Oh, hi.

FGF23 often rises early to compensate, sometimes before blood phosphate even looks abnormal.

That helps for a while, but when FGF23 stays high for a long time, it goes along with low active vitamin D, overworked parathyroid glands, a condition called secondary hyperparathyroidism, abnormal bone remodeling, and higher heart disease risk.

In this setting, high FGF23 is both a sign that mineral balance is off and possibly a contributor to the disease.

That's why it should always be read alongside kidney function, phosphate, calcium, vitamin D, and parathyroid hormone.

This system controls bone breakdown, but it also overlaps with the immune system because many immune cells use related signals.

Chronic inflammation can ramp up osteoclast activity and cause bone loss.

In obesity and type 2 diabetes, inflammatory signals, oxidative stress, changes in the hormones made by fat tissue called adipokines, and shifts in sex hormones may disturb both metabolism and bone remodeling.

Bone marrow adds another layer.