Bone morphogenetic protein 4
ProteinWikipedia
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Search complete. 2 mentions across 2 episodes found for "Bone morphogenetic protein 4".
Oct 1, 2026
John YuGUEST
And so what happens is, when a, a cancer is being treated, they become more like cancer stem cells, and then they become resistant to the drugs that are used to treat it.
John YuGUEST
And we found the actual biochemical mechanism by which this happens, and Neil Bommick, our chief scientific officer in the lab, identified a, a molecule on the cell called CD105, which then drives a gene that drives stem cells called BMP4, and it makes them more stem cell-like.
John YuGUEST
And so as they become more stem cell-like, they become resistant to the drugs that are used to treat it.
John YuGUEST
We've developed an antibody that targets the CD105, and so as we do that, they become less stem cell-like, and they lose that ability to withstand the drugs that are being used to treat it.
John YuGUEST
And so what happens is, when a, a cancer is being treated, they become more like cancer stem cells, and then they become resistant to the drugs that are used to treat it.
John YuGUEST
And we found the actual biochemical mechanism by which this happens, and Neil Bhowmick, our chief scientific officer in the lab, identified a, a molecule on the cell called CD105, which then drives a gene that drives stem cells called BMP4, and it makes them more stem cell-like.
John YuGUEST
And so as they become more stem cell-like, they become resistant to the drugs that are used to treat it.
John YuGUEST
We've developed an antibody that targets the CD105, and so as we do that, they become less stem cell-like, and they lose that ability to withstand the drugs that are being used to treat it.