bone marrow

It's on the DMOnline.com. Madeline Lass writing it.

Bone Marrow Donation Drive.

A name that's been familiar with our network as well.

We put some things out.

So can you highlight a little bit about what exactly mu cells are and how they're different from stem cells?

Yeah, so when I got involved in that clinical trial, we were using something called mesenchymal stem cells, which was basically we were isolating them from your bone marrow or from the fat, and then we would inject them back into your knee or hip, depending on where the issue was.

And then I started reading and I realized that the guy who made that term, mesenchymal stem cells, actually wrote a paper in 2017 saying, I was wrong.

They are not true stem cells.

So that's probably the biggest reason.

Unfortunately, I think it's just business and profitability.

And so are you able to get the mu cells both from bone marrow and from fat? And are there pros and cons to one? Like, say, do the ones from bone marrow work better on orthopedic conditions versus maybe the fat ones work better on autoimmunity or inflammation? Are there any kind of pros and cons to where they're sourced from?

Yeah, there hasn't been head-to-head clinical trials, but...

Shug is back.

Earlier this year, he had a bone marrow transplant and was given a .001% chance to live and proved all the doctors and YouTube commenters wrong.

He came back just to be on this podcast.

Shug, is any of this true?

But

he

never said that, though, did he? He never said that, but it was implied that, you know, we have some decisions to make about whether I want to, you know, go through and pursue this whole bone marrow transplant and go through all the chemotherapy or kind of call it and go, you know what, I'd rather just live out what I have.

And I was really leaning toward that at the time.

And today I want to talk about transplants from live donors.

And basically we're talking about the kidney, the liver, blood, bone marrow.

There's organic transplants, inorganic transplants.

And the question is, where does it start to discuss this? Where does the Torah talk about

The minor kinds of transplants are not really considered transplants.

They're donations of blood.

Bone marrow.

The donation of blood and bone marrow fulfills almost literally the biblical precept.

Dr. McNamara earned her Bachelor of Science from Hobart and William Smith Colleges in 2000, followed by her PhD in microbiology from the University in Pennsylvania in 2006.

Her research focuses on the hematopoietic system response to and recovers from stress caused by infection, inflammation and aging, with a particular emphasis on the critical role of macrophages in the bone marrow niche.

In recent years, she has brought specialized pro-resolving mediators into this field, demonstrating how SPMs, such as Resolving E1, can restore atherosclerosis, rescue marrow function in severe aplastic anemia, and how resolving D2 and related pathways influence macrophage senescence, aging, and atherosclerosis.

Her work is supported by major NIH funding, including her own R01 grant on inflammation resolution in bone marrow failure and the collaborative R01 with Dr. Gabrielle Fretman on resolution impairments in aging and atherosclerosis.

Dr. McNamara's research is helping to reveal how active resolution programs shape blood cell production and recovery.

And that's why we are delighted to have her on the SPM podcast today.

It's a tick-borne ehrlichiosis.

And one of the things about these diseases that, you know, was pretty well established clinically they caused very profound cytopenias like, and that was a sort of a hallmark of the disease, but it wasn't really clear why.

Yeah.

Yeah.This is too, probably too complex to be a name for a Bone Thugs-N-Harmony member, but I would say you call him Marrow because he's the bone filler.

He filled in the gaps.

He fills in the bones.

But then I, I don't think that ...

They would probably be confusing, and I understand why they might not pick that.

Bone Marrow.

Yeah, I like that though.

Okay.

Not fried, a bone marrow fried rice.

Oh, gross.

Okay.