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BHLHE41

BHLHE41

Search complete. 5 mentions across 3 episodes found for "BHLHE41".

Oct 7, 2026

speaker_0NARRATOR
43:32
Most adults need between seven and nine hours per night, though a small percentage of the population, estimated at less than three percent, functions well on fewer than six hours.
speaker_0NARRATOR
43:45
These true short resters carry a rare genetic variant in a gene called DEC2, which appears to allow their brains to accomplish the restorative functions more efficiently.
speaker_0NARRATOR
43:58
Researchers at the University of California, San Francisco, identified the DEC2 mutation in two thousand and nine after studying a family in which multiple members naturally got only about six hours per night without any apparent negative effects.
speaker_0NARRATOR
44:17
A second gene associated with natural short duration, called ADRB1, was identified by the same research group in twenty nineteen, and it appears to increase the activity of certain arousal-promoting neurons in the brain.
speaker_0NARRATOR
44:33
For the vast majority of people who do not carry these rare mutations, chronically getting less than seven hours per night is associated with a long list of health risks, including heart disease, diabetes, obesity, and impaired immune function.
speaker_4NARRATOR
46:41
Most adults need between seven and nine hours per night, though a small percentage of the population, estimated at less than three percent, functions well on fewer than six hours.
speaker_4NARRATOR
46:55
These true short resters carry a rare genetic variant in a gene called DEC2, which appears to allow their brains to accomplish the restorative functions more efficiently.
speaker_4NARRATOR
47:07
Researchers at the University of California, San Francisco, identified the DEC2 mutation in two thousand nine after studying a family in which multiple members naturally got only about six hours per night without any apparent negative effects.
speaker_4NARRATOR
47:26
A second gene associated with natural short duration, called ADRB1, was identified by the same research group in twenty nineteen, and it appears to increase the activity of certain arousal-promoting neurons in the brain.
speaker_4NARRATOR
47:43
For the vast majority of people who do not carry these rare mutations, chronically getting less than seven hours per night is associated with a long list of health risks, including heart disease, diabetes, obesity, and impaired immune function.
speaker_1HOST
19:52
They have no daytime cognitive deficits, no mood dysregulation.
speaker_1HOST
19:56
We've discovered this is genetically mediated mutations in genes like DEC2ADRB1 or BHLHE41.
speaker_1HOST
20:02
So
Manaan KarrayHOST
20:03
they just have better machinery?

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