Berberine

Yes, it is.

Berberine has been around for decades, if not centuries.

It's been around longer than glucophage and metformin.

They basically swiped the formula and got a patent on it and then got FDA approval.

Well, I'll give you my, you're right.

Berberine has been around, right? We've been using

it in GDAs

for a long time.

It's been around.

I think there was two things that really held it back.

And listen, a lot of people are still making money off Berberine.

And it's not to say that Berberine is not effective, but I think it just- But the GLP phase of it- And

The berberine lowered triglycerides by 17.5%, whereas the metformin group only brought them down by 4.5%.

And then they looked at LDL cholesterol.

Berberine brought it down by 21%, whereas metformin only brought it down by 2%.

That should be on the front page of the news, but of course you can't patent this.

You don't need a prescription, so it's not going to be recommended.

So we use a blend of d-chiro and myo-inositol in practice, which is widely studied to be a good blend.

Then berberine.

Berberine has some interesting research for glucose and lipid metabolism and insulin sensitivity, but it's not something I would recommend to everyone.

Definitely based on their medications, there can be some interactions.

For some people, it can cause GI issues.

Okay? This is very popular online.

Berberine, calling it nature's Ozempic.

Trash it.

Why?

But the big thing is, is like you got to change something, right? You can't have a bunch of glucose floating around in your body.

That's the biggest kicker to the whole thing, okay? All right, so let's start with the one that gets compared to a pharmaceutical drug, berberine.

Berberine's really good.

So this isn't a myth or anything because it's really close.

They've tested both.

They'll be in the newsletter at tribe1.substack.com. if you would like them later in paper form.

But here we go.

Cinnamon Berberine Golden Latte.

We want to, if they start to grow out of control, we want it to signal apoptosis.

Berberine can help with that.

What is apoptosis? Well, when a cell starts to divide unnaturally or mutate, there's a signal on the cell and that signals apoptosis.

That means cellular destruction.

It's going to hurt the body, so it sacrifices itself.

Now, cancer cells don't get those signals.

Berberine seems to be able to help.

The next one is oxidative stress and free radicals, so it can be great for overall cardiovascular risk and inflammation, of course.

There is interesting research looking at how berberine interacts with our metabolic pathways, including pathways involving GLP-1.

But going from this compound may affect GLP-1 signaling to this is nature's Ozempic is just an enormous unfounded leap.

Berberine is not a natural version of semaglutide.

The effects are not remotely comparable, and calling it nature's Ozempic is just marketing.

It's not an accurate description of what this supplement does.

Berberine may have legitimate applications, particularly in, you know, metabolic health and blood sugar management, but it also has side effects, and it can interact with medications.

So I would absolutely not treat this as a casual, like, I'm trying to lose five pounds, let me add berberine supplement.

If you're considering it because of, you know, blood sugar or metabolic concerns, that's a conversation you should be having with your healthcare provider.