BCL6
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Search complete. 5 mentions across 5 episodes found for "BCL6".
Sep 22, 2026
KaleHOST
If you see something described as colloquially a triple-hit or a double-hit lymphoma, that means they have two of the three high-grade mutations that we see associated with the large-cell lymphomas.
KaleHOST
That is a MYC rearrangement and one or both of a BCL2 and BCL6 mutation to make yourself either a triple, or if you have all of them, or a double-hit if you have one of them respectively.
KaleHOST
Don't worry if none of this makes any sense at all.
KaleHOST
We will talk more in the DLBCL episode on the difference between a lymphoma that expresses one of these markers by IHC or having a genetic mutation detectable by fish and how the combinations work.
Susan HudsonHOST
Because you're gonna lose eggs, and I think there's more than just losing eggs to those surgeries, that there's something structurally, biochemically, who knows, that they just don't react quite as well.
Susan HudsonHOST
And then either prophylactically giving Lupron or Orilissa for two months prior to embryo transfer in case there's BCL6, or if they wanna have BCL6 testing.
Susan HudsonHOST
Anytime you take medications that are gonna make you temporarily menopausal, it's not necessarily gonna be a fun thing to do.
Susan HudsonHOST
So some people would rather have the testing, plus your insurance is more likely to cover Lupron or, or ALESSE if you have positive testing.
Aimee EyvazzadehHOST
Right? It's basically the timestamp or the time for your evite for the embryo party.
Aimee EyvazzadehHOST
So the other test is looking at a hormone level or a protein called BCL6.
Aimee EyvazzadehHOST
It's a marker of inflammation and endometriosis in the lining of the uterus.
Aimee EyvazzadehHOST
So with that same biopsy that I do for the ERA test, I also send cells to this company as well.
Aimee EyvazzadehHOST
I'm actually gonna draw on the syringe, bringing cells into the catheter and sending them off to two labs.
Aimee EyvazzadehHOST
One lab tells me about inflammation, endometriosis, and BCL6 histologic score, and the other lab will tell me the number of hours of progesterone that your body needs in order for implantation to occur.
Aimee EyvazzadehHOST
Next question, do you test the uterine wall to make sure it's receptive? And the answer is yes.
Aimee EyvazzadehHOST
That's all part of doing the scratch.
speaker_0NARRATOR
The other major distinction is double-hit lymphoma.
speaker_0NARRATOR
This refers to rearrangements involving MYC and BCL2 and sometimes BCL6 depending on the classification.
speaker_0NARRATOR
These patients have particularly aggressive disease and generally require more intensive treatment than standard DLBCL.
speaker_0NARRATOR
Don't confuse this with double-expressor lymphoma.