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Bayesian inference

Bayesian inference

Search complete. 358 mentions across 75 episodes found for "Bayesian inference".

Sep 11, 2026

Type III AudioNARRATOR
0:35
From the third-person perspective you think of yourself as outside the world, looking in.
Type III AudioNARRATOR
0:40
You're a good Bayesian, in that you have a set of mutually exclusive collectively exhaustive hypotheses.
Type III AudioNARRATOR
0:46
You choose actions by multiplying your credences by your utilities over those hypotheses, and you treat those actions as the only way you influence the world.
Type III AudioNARRATOR
0:55
Some problems with the third-person perspective, a.k.a. Cartesian or dualistic agency, were described in Scott and Abrams' sequence on embedded agency.
Type III AudioNARRATOR
3:26
Such a theory would acknowledge unknown unknowns, as in the first perspective, but also give you a principled way of dealing with uncertainty, as in the third-person perspective.
Type III AudioNARRATOR
3:36
One intuitive picture I've been using.
Type III AudioNARRATOR
3:38
We can move towards a theory of Knightian uncertainty by considering Bayesian hypotheses with holes in them corresponding to Knightian regions which we can't model or control, for example other agents smarter than us.
Type III AudioNARRATOR
3:51
You can also think about the first-person perspective as coming from inside one of those holes, looking out.
Sonya Tang GirdwoodGUEST
49:11
You can get one, you can get three, kind of depends on the drug that you're studying and understanding a little bit about their pharmacokinetics.
Sonya Tang GirdwoodGUEST
49:20
And when you combine your population pharmacokinetic model with the observed concentrations, you can use something called Bayesian estimation within precision dosing software.
Sonya Tang GirdwoodGUEST
49:28
And then it can give you the best estimate of what they think is happening in your patient in front of you and what you think the concentration versus time profile is for that patient.
Sonya Tang GirdwoodGUEST
49:38
And then also estimate different pharmacokinetic parameters, such as volume and distribution and clearance.

6 MINS LATER

Rhodes HambrickGUEST
55:25
And that is one where I think the field, generally speaking, from what I was hearing at PAS and others' conversations, is that we should be moving more towards AUC-based monitoring of mycophenolate.
Rhodes HambrickGUEST
55:37
And so that's another one of the backbones of the pharmacokinetic consultation service that Dr. Tengred was mentioning at Cincinnati Children's.
Rhodes HambrickGUEST
55:48
calculating using that Bayesian software to be able to calculate a mycophenolate AUC because we know mycophenolate in particular has very strange pharmacokinetics and that it has a lot of enterohepatic recirculation.
Rhodes HambrickGUEST
56:00
And so unfortunately, there's not a single time point like a trough or a peak or a mid interval time where you could use that in isolation to be able to get a good surrogate of the AUC.
Zvi MowshowitzHOST
36:32
Those who reacted with indignation or confusion that one would call it worse.
Zvi MowshowitzHOST
36:36
Isaac King challenges that no, you would have interpreted any number as worse, you're supposed to be Bayesians.
Zvi MowshowitzHOST
36:43
To which I reply that this is not the case.
Zvi MowshowitzHOST
36:46
I would prefer to see less attempts than soul in a way that lines up with other observations in the model card.
David KippingHOST
6:14
So we'll call this the truncated window hypothesis.
David KippingHOST
6:18
So in my new paper I throw the awesome power of Bayesian statistics at these two puzzles to figure out which explanation, if any, works.
David KippingHOST
6:27
The two puzzles represent our data, or here our observations, features that require explanation by our model.
David KippingHOST
6:35
And here our model actually encompasses all three hypotheses.
David KippingHOST
6:52
Let's use the symbol TWin.
David KippingHOST
6:55
Subtly, the look hypothesis is implicitly built into this because we can always evaluate this model at the extreme ends where both effects are negated.
David KippingHOST
7:05
So, in Bayesian parlance, our task is to figure out or infer this probability distribution.
David KippingHOST
7:11
The probability of getting various values of mcrit and twin given the data in hand, which here is our two puzzles.
NicholasGUEST
8:47
And this is the percentage of participants with treatment-related adverse events or serious adverse events, again, within 30 days after surgery.
NicholasGUEST
8:59
We used a pre-specified Bayesian analysis method, which combines prior evidence with current trial data, as is the appropriate framework within Bayesian analysis.
NicholasGUEST
9:13
Bayesian analysis provides a posterior probability, i.e. looking back at the study as to whether a real treatment benefit exists.
NicholasGUEST
9:23
You can compare this to a frequentist analysis, which is a more complex statistical question of whether the treatment could have produced an outcome that it did, should the hypothesis have been it didn't, which is a rather complex statistical question.
NicholasGUEST
9:41
This question, whether or not a likelihood is a real treatment benefit exists, is an appropriate one for a study like ours.
NicholasGUEST
10:03
There are hospitals with fewer beds in one surgical category than another.
NicholasGUEST
10:07
There are hospitals that take patients from certain populations within the community and not others.
NicholasGUEST
10:14
not a homogeneous income population and sparse outcomes ideal for Bayesian analysis.
speaker_1HOST
5:56
It feels like it at first, yeah.
speaker_0HOST
5:57
The article mentions this optimizer called MIPRV2, and my understanding is that you provide a small validation set of your own data, and then it uses a teacher model alongside a Bayesian search to find the best phrasing.
speaker_1HOST
6:11
That's exactly right.
speaker_0HOST
6:12
But when we say Bayesian search, is it literally like a- Mutating the prompt slightly, running it through the validation set, scoring the results, and then using those scores to mathematically predict a better mutation for the next round.
speaker_1HOST
6:26
That is the exact mechanism under the hood.
speaker_1HOST
6:28
So you have your validation data, let's say, I don't know, 50 examples of good inputs and outputs.
speaker_1HOST
6:41
It essentially brainstorms various ways to ask the target model to do the task.
speaker_0HOST
6:46
Oh, I see.
Kevin ColeGUEST
30:04
Sure, sure.
Kevin ColeGUEST
30:05
So I do something where I've found, you know, it's a Bayesian model where it uses what they call the normal, normal distribution.
Kevin ColeGUEST
30:12
So it assumes, which is roughly correct, that there is a normal distribution of performance when we look at a quarterback level for their efficiency.
Kevin ColeGUEST
30:22
So I'm looking at that.

7 MINS LATER

Kevin ColeGUEST
37:27
I think really after a full season, you don't care about draft position that much, but especially after two years in the NFL.
Kevin ColeGUEST
37:34
Yeah.
Eric BradlowHOST
37:35
So let me ask you, thanks to Cade for putting your Bayesian quarterback rankings into the rundown.
Eric BradlowHOST
37:41
I'm surprised.
Type Three AudioNARRATOR
32:53
Those who reacted with indignation or confusion that one would call it worse.
Type Three AudioNARRATOR
32:59
Isaac King challenges that no, you would have interpreted any number as worse, you are supposed to be Bayesians.
Type Three AudioNARRATOR
33:05
To which I reply that this is not the case.
Type Three AudioNARRATOR
33:08
I would prefer to see less attempts than Sol in a way that lines up with other observations in the model card.
Type 3 AudioNARRATOR
32:59
Isaac King challenges that, "No, you would have interpreted any number as worse.
Type 3 AudioNARRATOR
33:02
You're supposed to be Bayesians." To which I reply that this is not the case.
Type 3 AudioNARRATOR
33:08
I would prefer to see less attempts than Sol in a way that lines up with other observations in the model card.
Type 3 AudioNARRATOR
33:14
I would see this as good news on the margin up until a roughly fifty percent to seventy-five percent reduction in attempts.
UrbanHOST
24:43
Is Maxwell's demon a real demon? Well, this is where it gets interesting.
UrbanHOST
24:51
So there's a paper published in February 2026, we've mentioned it briefly, titled Sycophantic Chatbots, which caused delusional spiraling even in ideal Bayesians, sane people, normal, uh, average person.
UrbanHOST
25:08
This research investigates the dangerous phenomenon of delusional spiraling where AI users develop extreme confidence in false or outlandish beliefs through extended interactions with chatbots using a Bayesian model to simulate conversations.
UrbanHOST
25:24
The authors demonstrate that sycophancy, this being the tendency of AI or anybody could be a human doing it as well, to prioritize user validation over objective truth.

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