Bayesian inference
358
MENTIONS
75
EPISODES
63
PODCASTS
Search complete. 358 mentions across 75 episodes found for "Bayesian inference".
Sep 11, 2026
"Explaining Knightianism on one foot" by Richard_Ngo
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0:35Type III AudioNARRATOR
From the third-person perspective you think of yourself as outside the world, looking in.
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0:40Type III AudioNARRATOR
You're a good Bayesian, in that you have a set of mutually exclusive collectively exhaustive hypotheses.
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0:46Type III AudioNARRATOR
You choose actions by multiplying your credences by your utilities over those hypotheses, and you treat those actions as the only way you influence the world.
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0:55Type III AudioNARRATOR
Some problems with the third-person perspective, a.k.a. Cartesian or dualistic agency, were described in Scott and Abrams' sequence on embedded agency.
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3:26Type III AudioNARRATOR
Such a theory would acknowledge unknown unknowns, as in the first perspective, but also give you a principled way of dealing with uncertainty, as in the third-person perspective.
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3:36Type III AudioNARRATOR
One intuitive picture I've been using.
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3:38Type III AudioNARRATOR
We can move towards a theory of Knightian uncertainty by considering Bayesian hypotheses with holes in them corresponding to Knightian regions which we can't model or control, for example other agents smarter than us.
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3:51Type III AudioNARRATOR
You can also think about the first-person perspective as coming from inside one of those holes, looking out.
Episode 51: Drug Dosing in Renal Replacement Therapy
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49:11Sonya Tang GirdwoodGUEST
You can get one, you can get three, kind of depends on the drug that you're studying and understanding a little bit about their pharmacokinetics.
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49:20Sonya Tang GirdwoodGUEST
And when you combine your population pharmacokinetic model with the observed concentrations, you can use something called Bayesian estimation within precision dosing software.
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49:28Sonya Tang GirdwoodGUEST
And then it can give you the best estimate of what they think is happening in your patient in front of you and what you think the concentration versus time profile is for that patient.
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49:38Sonya Tang GirdwoodGUEST
And then also estimate different pharmacokinetic parameters, such as volume and distribution and clearance.
6 MINS LATER
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55:25Rhodes HambrickGUEST
And that is one where I think the field, generally speaking, from what I was hearing at PAS and others' conversations, is that we should be moving more towards AUC-based monitoring of mycophenolate.
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55:37Rhodes HambrickGUEST
And so that's another one of the backbones of the pharmacokinetic consultation service that Dr. Tengred was mentioning at Cincinnati Children's.
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55:48Rhodes HambrickGUEST
calculating using that Bayesian software to be able to calculate a mycophenolate AUC because we know mycophenolate in particular has very strange pharmacokinetics and that it has a lot of enterohepatic recirculation.
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56:00Rhodes HambrickGUEST
And so unfortunately, there's not a single time point like a trough or a peak or a mid interval time where you could use that in isolation to be able to get a good surrogate of the AUC.
GPT-6 Astra: The System Card, Alignment and What Comes Next
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36:32Zvi MowshowitzHOST
Those who reacted with indignation or confusion that one would call it worse.
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36:36Zvi MowshowitzHOST
Isaac King challenges that no, you would have interpreted any number as worse, you're supposed to be Bayesians.
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36:43Zvi MowshowitzHOST
To which I reply that this is not the case.
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36:46Zvi MowshowitzHOST
I would prefer to see less attempts than soul in a way that lines up with other observations in the model card.
Why Intelligent Life May Be Impossible Around Most Stars
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6:14David KippingHOST
So we'll call this the truncated window hypothesis.
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6:18David KippingHOST
So in my new paper I throw the awesome power of Bayesian statistics at these two puzzles to figure out which explanation, if any, works.
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6:27David KippingHOST
The two puzzles represent our data, or here our observations, features that require explanation by our model.
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6:35David KippingHOST
And here our model actually encompasses all three hypotheses.
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6:52David KippingHOST
Let's use the symbol TWin.
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6:55David KippingHOST
Subtly, the look hypothesis is implicitly built into this because we can always evaluate this model at the extreme ends where both effects are negated.
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7:05David KippingHOST
So, in Bayesian parlance, our task is to figure out or infer this probability distribution.
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7:11David KippingHOST
The probability of getting various values of mcrit and twin given the data in hand, which here is our two puzzles.
ONDINE BIOMEDICAL INC. - Investor Presentation of Phase 3 Topline Results
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8:47NicholasGUEST
And this is the percentage of participants with treatment-related adverse events or serious adverse events, again, within 30 days after surgery.
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8:59NicholasGUEST
We used a pre-specified Bayesian analysis method, which combines prior evidence with current trial data, as is the appropriate framework within Bayesian analysis.
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9:13NicholasGUEST
Bayesian analysis provides a posterior probability, i.e. looking back at the study as to whether a real treatment benefit exists.
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9:23NicholasGUEST
You can compare this to a frequentist analysis, which is a more complex statistical question of whether the treatment could have produced an outcome that it did, should the hypothesis have been it didn't, which is a rather complex statistical question.
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9:41NicholasGUEST
This question, whether or not a likelihood is a real treatment benefit exists, is an appropriate one for a study like ours.
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10:03NicholasGUEST
There are hospitals with fewer beds in one surgical category than another.
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10:07NicholasGUEST
There are hospitals that take patients from certain populations within the community and not others.
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10:14NicholasGUEST
not a homogeneous income population and sparse outcomes ideal for Bayesian analysis.
🍝 Stop writing prompt spaghetti.
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5:56speaker_1HOST
It feels like it at first, yeah.
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5:57speaker_0HOST
The article mentions this optimizer called MIPRV2, and my understanding is that you provide a small validation set of your own data, and then it uses a teacher model alongside a Bayesian search to find the best phrasing.
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6:11speaker_1HOST
That's exactly right.
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6:12speaker_0HOST
But when we say Bayesian search, is it literally like a- Mutating the prompt slightly, running it through the validation set, scoring the results, and then using those scores to mathematically predict a better mutation for the next round.
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6:26speaker_1HOST
That is the exact mechanism under the hood.
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6:28speaker_1HOST
So you have your validation data, let's say, I don't know, 50 examples of good inputs and outputs.
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6:41speaker_1HOST
It essentially brainstorms various ways to ask the target model to do the task.
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6:46speaker_0HOST
Oh, I see.
Is this NFL season more wide open than it appears?
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30:04Kevin ColeGUEST
Sure, sure.
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30:05Kevin ColeGUEST
So I do something where I've found, you know, it's a Bayesian model where it uses what they call the normal, normal distribution.
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30:12Kevin ColeGUEST
So it assumes, which is roughly correct, that there is a normal distribution of performance when we look at a quarterback level for their efficiency.
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30:22Kevin ColeGUEST
So I'm looking at that.
7 MINS LATER
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37:27Kevin ColeGUEST
I think really after a full season, you don't care about draft position that much, but especially after two years in the NFL.
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37:34Kevin ColeGUEST
Yeah.
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37:35Eric BradlowHOST
So let me ask you, thanks to Cade for putting your Bayesian quarterback rankings into the rundown.
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37:41Eric BradlowHOST
I'm surprised.
“GPT-6 Astra: The System Card, Alignment and What Comes Next” by Zvi
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32:53Type Three AudioNARRATOR
Those who reacted with indignation or confusion that one would call it worse.
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32:59Type Three AudioNARRATOR
Isaac King challenges that no, you would have interpreted any number as worse, you are supposed to be Bayesians.
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33:05Type Three AudioNARRATOR
To which I reply that this is not the case.
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33:08Type Three AudioNARRATOR
I would prefer to see less attempts than Sol in a way that lines up with other observations in the model card.
“GPT-6 Astra: The System Card, Alignment and What Comes Next” by Zvi
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32:59Type 3 AudioNARRATOR
Isaac King challenges that, "No, you would have interpreted any number as worse.
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33:02Type 3 AudioNARRATOR
You're supposed to be Bayesians." To which I reply that this is not the case.
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33:08Type 3 AudioNARRATOR
I would prefer to see less attempts than Sol in a way that lines up with other observations in the model card.
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33:14Type 3 AudioNARRATOR
I would see this as good news on the margin up until a roughly fifty percent to seventy-five percent reduction in attempts.
Vacuum Tubes, Microprocessors & Maxwell's Demon (Pt. II) [Sept. 7th, 2026]
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24:43UrbanHOST
Is Maxwell's demon a real demon? Well, this is where it gets interesting.
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24:51UrbanHOST
So there's a paper published in February 2026, we've mentioned it briefly, titled Sycophantic Chatbots, which caused delusional spiraling even in ideal Bayesians, sane people, normal, uh, average person.
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25:08UrbanHOST
This research investigates the dangerous phenomenon of delusional spiraling where AI users develop extreme confidence in false or outlandish beliefs through extended interactions with chatbots using a Bayesian model to simulate conversations.
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25:24UrbanHOST
The authors demonstrate that sycophancy, this being the tendency of AI or anybody could be a human doing it as well, to prioritize user validation over objective truth.
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