Ataxia telangiectasia and Rad3 related
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Search complete. 4 mentions across 2 episodes found for "Ataxia telangiectasia and Rad3 related".
Sep 10, 2026
Islam MohamedGUEST
The field had recognized this a long time ago.
Islam MohamedGUEST
You know, there are other possible targets in DNA damage response, and that space is pretty crowded with active programs directed at ATR or ATM or WeOne, CheckOne, PollQ.
Islam MohamedGUEST
You know, investors that are familiar with this space would be familiar with those targets as well.
Islam MohamedGUEST
And several of them are from well-capitalized companies.
12 MINS LATER
Islam MohamedGUEST
So that means that no one else appears to have taken this particular target into humans.
Islam MohamedGUEST
The genuine competition is the DNA damage response class more largely.
Islam MohamedGUEST
So PARP is mature and commercialized, and behind it sits programs directed at ATR, ATM, WE1, CHECK1, pole Q, you know, these other DNA damage response targets are in varying stages of development as well.
Islam MohamedGUEST
And some of them are from well-capitalized biotechnology companies pursuing a similar logic, but at different points in the repair pathway.
Islam MohamedGUEST
The tumor can restore DNA damage and resistant subpopulations of the cancer can persist and the disease can return.
Islam MohamedGUEST
The field had recognized this a long time ago, You know, there are other possible targets in DNA damage response, and that space is pretty crowded with active programs directed at ATR or ATM or WeOne, CheckOne, PollQ.
Islam MohamedGUEST
You know, investors that are familiar with this space would be familiar with those targets as well.
Islam MohamedGUEST
And several of them are from well-capitalized companies.
12 MINS LATER
Islam MohamedGUEST
So that means that no one else appears to have taken this particular target into humans.
Islam MohamedGUEST
The genuine competition is the DNA damage response class more largely.
Islam MohamedGUEST
So PARP is mature and commercialized, and behind it sits programs directed at ATR, ATM, WE1, CHECK1, You know, these other DNA damage response targets are in varying stages of development as well.
Islam MohamedGUEST
And some of them are from well-capitalized biotechnology companies pursuing a similar logic, but at different points in the repair pathway.